Postdoctoral Fellow, Protein Sciences, Kschonsak Lab

Genentech; South San Francisco (CA); On-site; USD 100,000 - 106,500; Full time

Benefits offered by this job

Relocation benefits

Postdoc program

Job summary

Genentech in South San Francisco invites applications for a Postdoctoral Fellow in the Protein Engineering and Structural Biology Group. The role focuses on membrane protein biology, structure and signaling complexes, using cryo-EM and crystallography.

The successful candidate will have a Ph.D., experience purifying challenging membrane proteins, and independence to design experiments. Collaboration across labs and presenting at conferences are expected.

Qualifications

• Ph.D. in a relevant field with first-author publications in high-impact journals.
• Experience with expression and purification of challenging proteins.
• Experience with single-particle cryo-EM and/or X-ray crystallography sample prep, data collection, and processing.
• Independent and capable of designing, executing, and troubleshooting complex workflows.
• Strong collaborative spirit to work with others in a team.
• Strong oral and written communication skills.

Responsibilities

• Answer fundamental questions in membrane protein biology.
• Investigate structural and functional mechanisms of transmembrane proteins and signaling complexes.
• Collaborate with Genentech and academic labs; present work at conferences.
• Utilize state-of-the-art structural biology facilities and contribute to publications.

Skills

PhD required

Protein purification

Cryo-EM/X-ray

Independent researcher

Team collaboration

Communication skills

Education

Ph.D. in a relevant field

Tools

Cryo-EM

X-ray crystallography

Job description

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.

The Opportunity:

A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Marc Kschonsak in the Protein Engineering and Structural Biology Group within the Protein Sciences Department at Genentech. In this role, you will answer fundamental questions in membrane protein biology, focusing on the structural and functional mechanisms of transmembrane proteins, and their associated macromolecular signaling complexes

The Kschonsak Lab works on the biochemical and structural mechanisms of novel membrane proteins and their larger, endogenous signaling assemblies. We leverage a highly multidisciplinary approach - combining cryo-EM, endogenous purifications, and functional reconstitution to understand how these complex systems operate across both recombinant and endogenous contexts.

In this role, you will have access to state-of-the-art structural biology and biophysical equipment and facilities. In addition, you will have opportunities to collaborate with other labs both within Genentech and in academia, and present your work at conferences.

Who You Are:

• Ph.D. in a Relevant Field: You hold a Ph.D. with a proven track record of creativity, rigor, and success in structural biology, biochemistry, biophysics, or a related field, as exemplified by first-author publication(s) in high-impact journals.
• Protein Purification: Experience with expression and purification of challenging proteins is required
• Structural Biology Foundation: Experience with single-particle cryo-EM and/or X-ray crystallography sample preparation, data collection, and processing is required.
• Scientific Independence: You are independent and capable of designing, executing, and troubleshooting complex biochemistry and structural biology workflows to answer challenging biological questions.
• Collaborative Spirit: A strong collaborative spirit to work with others in a team to bring projects to fruition is needed.
• Communication Skills: Strong oral and written communication skills are required.

Preferred Qualifications:

• Membrane Protein Expertise: Successful experience with the expression and purification of membrane proteins is highly desirable.
• Biochemical Functional Assays: Successful experience with the reconstitution of membrane proteins into lipid environments (e.g., liposomes, nanodiscs) and establishing functional transport or signaling assays.
• Endogenous Purifications: Experience in isolating endogenous complexes from tissues or cell lines.
• Cellular Assays: Experience with mammalian cell culture, heterologous expression, or cellular functional assays

For information about the Kschonsak lab, please go to:

https://scholar.google.com/citations?user=DRa8vIIAAAAJ&hl=de

https://www.gene.com/scientists/our-scientists/marc-kschonsak

The expected salary range for this position based on the primary location of South San Francisco California is $100,000 to $106,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are available for this job posting.

Postdoc Program

Elevate your research career to new heights with Genetech’s Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities.

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