Postdoctoral Fellow - Pancreatic Cancer

City of Hope; Duarte (CA); On-site; USD 60,000 - 75,000; Full time

Job summary

City of Hope in Duarte, CA seeks a Postdoctoral Fellow in Dr. Jen Yeh's laboratory to advance cancer genomics and pharmacogenomics research in pancreatic cancer.

The role focuses on computational method development, data analysis, and experimental design, integrating high-throughput screens, proteomics, and NGS data to generate and validate therapeutically relevant hypotheses. The successful candidate will work with a multidisciplinary team, contribute to study design, manage large datasets, and

Qualifications

• Ph.D. in Bioinformatics, Genetics, Genomics, or an equivalent field.
• Experience with common experimental techniques in molecular biology.
• Experience working with mouse models.
• Experience handling large datasets.

Responsibilities

• Focus on cancer genomics and personalized medicine, with responsibilities that include computational method development, data analysis, and experimental design.
• Integrate information from high-throughput screens, proteomic data, and next-generation sequencing data to generate and validate hypotheses of therapeutic relevance to pancreatic cancer.

Skills

Molecular biology techniques

Mouse models

Data analysis

Linux environments

R or MATLAB

Education

Ph.D. in Bioinformatics, Genetics, Genomics, or equivalent

Job description

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life‑threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

The Beckman Research Institute of City of Hope is seeking a highly motivated Postdoctoral Fellow to join Dr. Jen Jen Yeh’s laboratory. The laboratory aims to understand the pathogenesis and pharmacogenomics of pancreatic cancer in order to accelerate treatment. Using a combination of molecular and genomic data and human-in-mouse models, the lab has identified four core subtypes in pancreatic cancer with important biologic and clinical implications.

As a successful candidate you will:

• Focus on cancer genomics and personalized medicine, with responsibilities that include computational method development, data analysis, and experimental design.
• Integrate information from high-throughput screens, proteomic data, and next-generation sequencing data to generate and validate hypotheses of therapeutic relevance to pancreatic cancer.

Your qualifications should include:

• Ph.D. in Bioinformatics, Genetics, Genomics, or an equivalent field.
• Experience with common experimental techniques in molecular biology.
• Experience working with mouse models.
• Experience handling large datasets.

Preferred qualifications:

• Thorough knowledge of cancer biology, epigenetics, proteomics, and transcriptomics.
• Familiarity with next-generation sequencing data analysis tools.
• Experience working in Linux environments, including batch job management on shared computing resources.
• Familiarity with a variety of supervised and unsupervised classification techniques.
• Proficiency in one or more statistical or scripting languages, preferably R or MATLAB.
• Knowledge of survival-based statistical analysis, such as Cox regression and Kaplan-Meier analysis.
• Working knowledge of machine learning best practices to avoid overfitting.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.