Postdoctoral Fellow-MSH-32035-054

Mount Sinai Health System; United States; On-site; USD 75,000 - 80,000; Full time

Job summary

Mount Sinai Health System (DOMI) invites a postdoctoral fellow to study pancreatic beta-cell biology, focusing on mechanisms of beta-cell failure and stress resilience in metabolic disease. The role involves leading work on transcription factor dynamics and novel therapeutic small-molecule glues to protect beta-cells from glucolipotoxicity and cytokine stress.

The position requires hands-on mouse handling, core molecular biology and biochemistry work, and returning high-impact publications; a

Qualifications

• Ph.D., M.D./Ph.D., or equivalent in Molecular Biology/Biochemistry/Biomedical Sciences or related field.
• Strong background in molecular biology and biochemistry is required.
• Prior hands-on experience with mouse handling and in vivo protocols is required.
• Experience in pancreatic islet biology is highly preferred.

Responsibilities

• Mandatory hands-on mouse handling.
• Core molecular biology and biochemistry protocols.
• Confocal imaging.
• NGS sequencing and analysis (optional).

Skills

Mouse handling

Molecular biology

Biochemistry techniques

In vivo protocols

Education

PhD or MD/PhD in Molecular Biology or related field

Tools

Confocal Imaging

NGS sequencing/analysis

Job description

Salary: Commensurate with experience, in accordance with NIH and Icahn School of Medicine at Mount Sinai guidelines.

Department: Diabetes, Obesity and Metabolism Institute (DOMI)

Physical work location: (must be proper street address) 1428 Madison Ave, Atran building 5 th floor

Name PI or Supervisor: (include phone and email) Liora Katz, [e-mail]

Web link to Lab: https://profiles.icahn.mssm.edu/liora-s-katz

Administrative Contact: Jessica Correa- [e-mail]

Details of Research Project:

The laboratory investigates pancreatic beta-cell biology, focusing on the mechanisms of beta-cell failure, adaptive expansion, and stress resilience in metabolic disease. Supported by multiple active NIH R01 and R03 grants, this project specifically evaluates transcription factor dynamics, including the ChREBP axis, and cytoprotective mechanisms. The incoming postdoctoral fellow will lead efforts to study early drivers of beta-cell failure and evaluate novel therapeutic small-molecule 14-3-3 molecular glues (such as Compound 43) designed to shield beta-cells from glucolipotoxicity and cytokine stress.

Technical Duties:

• Mandatory hands-on mouse handling
• Core molecular biology and biochemistry protocols.
• Confocal Imaging
• NGS sequencing and analysis (optional)

Educational and other Requirements for the position:

Ph.D., M.D./Ph.D., or equivalent degree in Molecular Biology, Biochemistry, Biomedical Sciences, or a closely related discipline.

Experience Required:

Candidates must possess a strong, demonstrable background in molecular biology and biochemistry. Mandatory hands-on experience in mouse handling and in vivo protocols is required. Prior expertise in pancreatic islet biology is highly preferred.

Goals/Outcomes of the Research Project:

To elucidate the pathways mediating beta-cell failure and validate therapeutic interventions utilizing molecular glues to preserve beta-cell mass and function. The fellow will be expected to drive the project toward high-impact peer-reviewed publications, present research at national/international conferences (such as the ADA Scientific Sessions or HIRN meetings), and contribute to grant applications.

Compensation Statement:

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 021 - Metabolism Institute - ISM, Icahn School of Medicine