Postdoctoral Fellow-MSH-30035-400

Mount Sinai Medical Center; New York (NY); On-site; USD 75,000 - 80,000; Full time

Job summary

Mount Sinai Health System in New York City seeks a PhD-level researcher to investigate how Sirt7 modulates D1-type medium spiny neurons and synaptic pathways to promote resilience against compulsive alcohol drinking. You will perform behavioral experiments, manage mouse colonies, and conduct stereotaxic procedures.

The role emphasizes transcriptional and epigenetic regulation in the dorsomedial striatum, with a focus on histone acetylation and resilience mechanisms, under the supervision of

Qualifications

• PhD in Biological Science is required.
• At least 5 years of experience working with laboratory mice.
• Experience with behavioral experiments and mouse handling is expected.

Responsibilities

• Conduct alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms.
• Maintain and manage mouse colonies; perform stereotaxic surgeries and related procedures.
• Monitor animals during behavioral studies and collect brain tissue for downstream analyses.
• Document and report experimental findings to supervisory personnel.

Skills

Mouse handling

Behavioral experiments

Stereotaxic surgeries

Histone acetylation

D1-MSNs research

Education

PhD in Biological Science

Tools

Stereotaxic apparatus

Behavioral assay equipment

Job description

Description

Salary: $74,692

Department: Neuroscience

Physical work location: 1415 Madison Avenue, 10-20A, New York, NY 10029

Name PI or Supervisor: Daniel Almeida da Silva e Silva, 2404782169, [e-mail]

Web link to Lab: dasilvalab.org

Web link to Department: https://icahn.mssm.edu/about/departments-offices/neuroscience

Administrative Contact: 212 659 1692, [e-mail]

Responsibilities

Details of Research Project:

We will investigate the role of Sirt7, a histone deacetylase, in D1-type medium spiny neurons (D1-MSNs), focusing on how it shapes synaptic plasticity and modulates resilience to compulsive alcohol drinking. Our central hypothesis is that that epigenetic changes in D1-MSNs of the dorsomedial striatum, driven primarily by histone acetylation and modulated by Sirt7, promote transcriptional and synaptic adaptations that jointly confer resilience to compulsive-like drinking. The rationale for this project is grounded in compelling preliminary data suggesting that transcriptional changes in the histone acetylation process, particularly those regulated by Sirt7, are associated with reduced compulsive-like drinking in mice

through the transcriptional control of synaptic pathways.

Technical Duties: (include any protocols)

Responsibilities will include conducting alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms; maintaining and managing mouse colonies; performing stereotaxic surgeries and related experimental procedures; monitoring animals throughout behavioral studies; and collecting brain tissue for downstream molecular and cellular analyses.

Qualifications

Educational and other Requirements for the position: PhD in Biological Science

Experience Required: At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments.

Goals/Outcomes of the Research Project: Identify mechanisms that promote resilience to compulsive alcohol drinking, a clinically relevant phenotype of AUD characterized by continued drinking despite adverse consequences.

Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.