Postdoctoral Fellow-MSH-30035-400

Mount Sinai; Madison (WI); On-site; USD 75,000 - 80,000; Full time

Job summary

Mount Sinai Health System seeks a highly qualified postdoctoral researcher to investigate the role of Sirt7 in D1-MSNs and its effects on synaptic plasticity and resilience to compulsive alcohol drinking. The role includes conducting alcohol-related behavioral experiments, managing mouse colonies, performing stereotaxic surgeries, and collecting tissue for analysis.

The candidate should have a PhD in Biological Science and at least 5 years of experience with laboratory mice.

Qualifications

• PhD in Biological Science is required.
• At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments.
• Experience with stereotaxic surgeries and brain tissue collection is desirable.

Responsibilities

• Conduct alcohol-related behavioral experiments, including operant self-administration.
• Maintain and manage mouse colonies and perform stereotaxic surgeries and related procedures.
• Monitor animals during behavioral studies and collect brain tissue for analyses.

Skills

Mouse handling

Behavioral experiments

Education

PhD in Biological Science

Job description

Salary: $74,692

Department: Neuroscience

Physical work location: 1415 Madison Avenue, 10-20A, New York, NY 10029

Name PI or Supervisor: Daniel Almeida da Silva e Silva, 2404782169, [e-mail]

Web link to Lab: dasilvalab.org

Web link to Department: https://icahn.mssm.edu/about/departments-offices/neuroscience

Administrative Contact: 212 659 1692, [e-mail]

Details of Research Project:

We will investigate the role of Sirt7, a histone deacetylase, in D1-type medium spiny neurons (D1-MSNs), focusing on how it shapes synaptic plasticity and modulates resilience to compulsive alcohol drinking. Our central hypothesis is that that epigenetic changes in D1-MSNs of the dorsomedial striatum, driven primarily by histone acetylation and modulated by Sirt7, promote transcriptional and synaptic adaptations that jointly confer resilience to compulsive-like drinking. The rationale for this project is grounded in compelling preliminary data suggesting that transcriptional changes in the histone acetylation process, particularly those regulated by Sirt7, are associated with reduced compulsive-like drinking in mice

through the transcriptional control of synaptic pathways.

Technical Duties: (include any protocols)

Responsibilities will include conducting alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms; maintaining and managing mouse colonies; performing stereotaxic surgeries and related experimental procedures; monitoring animals throughout behavioral studies; and collecting brain tissue for downstream molecular and cellular analyses.

Educational and other Requirements for the position: PhD in Biological Science

Experience Required: At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments.

Goals/Outcomes of the Research Project: Identify mechanisms that promote resilience to compulsive alcohol drinking, a clinically relevant phenotype of AUD characterized by continued drinking despite adverse consequences.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 867 - Neurosciences - ISM, Icahn School of Medicine

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Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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