Postdoctoral Fellow-MSH-30035-390

Mount Sinai Health System; New York (NY); On-site; USD 72,500 - 80,000; Full time

Job summary

Mount Sinai Health System is looking for a researcher to lead core experimental work on Alzheimer's treatment using deep brain stimulation (DBS-f). The ideal candidate will have a PhD in a relevant field, expertise in coding and analysis of neural datasets, and experience in behavioral neuroscience with nonhuman primates. The role offers a salary between $72,500 and $80,000 annually, aiming to foster collaboration and innovation in neuroscientific research.

Qualifications

• Doctorate required in relevant discipline.
• Knowledge of neural dataset analysis essential.
• Experience with behavioral neuroscience techniques preferred.

Responsibilities

• Lead core experiments using large-scale Neuropixels recordings.
• Work with experts to apply findings to Alzheimer's treatments.
• Mentor junior lab members and present research findings.

Skills

Laboratory experience in behavioral neuroscience

Analysis of behavioral and neural datasets

Proficiency in coding (MATLAB or Python)

Education

PhD in Neuroscience, Biomedical Engineering, Psychology, Electrical Engineering, or related field

Tools

MATLAB

Python

Job description

Description

Details of Research Project: How can neuroscience help us design and optimize treatments for devastating disorders of learning and memory? Our lab directly addresses this challenge by leveraging our experimental platform to understand, test, and optimize therapeutic interventions for cognitive disorders. This project focuses on fornix deep brain stimulation (DBS-f)—a promising treatment for Alzheimer’s disease currently in Phase III clinical trials. The mechanism of this therapy is not known. We will combine DBS-f with our large-scale recording platform to provide a mechanistic, circuit-level explanation for its effects, with the long-term goal of optimizing its clinical application.

Technical Duties

Lead core experiments using large-scale Neuropixels recordings and patterned microstimulation (DBS) in behaving primates navigating immersive virtual reality environments. Work with world-renowned clinicians and DBS experts to translate circuit-level findings into frameworks for understanding and treating Alzheimer’s disease and related dementias. Investigate circuit-level mechanisms of emerging therapies, specifically the effects of fornix DBS on neural computation. Mentor junior lab members and contribute to the development of a growing research team. Present findings at international conferences (e.g., Gordon Research Conference, Society for Neuroscience) and prepare manuscripts for high-impact publications.

• Leading complex experiments using large-scale Neuropixels recordings and patterned microstimulation (DBS) in behaving primates navigating immersive virtual reality environments.
• Collaborating with clinicians and DBS experts to translate circuit-level findings into frameworks for understanding and treating Alzheimer’s disease and related dementias.
• Investigating the circuit-level mechanisms of emerging therapies, focusing on fornix DBS effects on neural computation.
• Mentoring junior lab members and assisting in the development of the research team.
• Presenting findings at international conferences and preparing manuscripts for high-impact publications.

Responsibilities

Experience Required:

• Laboratory experience in behavioral neuroscience, preferably with nonhuman primates
• Analysis of behavioral and neural datasets
• Proficiency in coding (MATLAB or Python) for data acquisition and analysis

Goals/Outcomes Of The Research Project

• Mechanistic Understanding: Elucidate circuit-level mechanisms by which DBS-f alters neural representations in the hippocampus and prefrontal cortex to improve learning and memory.
• Therapeutic Optimization: Establish a framework for predicting and explaining the variable efficacy of DBS treatments, paving the way for optimized clinical protocols.
• Career Advancement: Produce high-quality datasets leading to first-author publications in top-tier journals and support the fellow’s transition to an independent research career.
• Technological Innovation: Advance the use of large-scale recording technologies (Neuropixels) combined with neuromodulation in awake, behaving primates.

Qualifications

Educational and other Requirements for the position:

• A PhD in Neuroscience, Biomedical Engineering, Psychology, Electrical Engineering, or a related field.
• Proficiency in coding (MATLAB or Python) for data acquisition and analysis.
• A strong interest in bridging the gap between basic circuit mechanisms and translational applications.

Employer Description

Strength through Unity and Inclusion: The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.