Postdoctoral Fellow-MSH-30020-173

Mount Sinai Health Systems; New York (NY); On-site; USD 67,000 - 82,000; Full time

Job summary

Mount Sinai Health System seeks highly skilled scientists to join the Blanchard Laboratory, studying how genetic and environmental factors influence the brain’s vulnerability to neurodegenerative disease. The lab uses human iPSC-based brain models, organoids, and assembloids, integrating multi-omics and computational analyses to uncover mechanisms and identify therapeutic strategies.

Ideal candidates hold a PhD with 4–5 years of relevant experience and have strong expertise in neurodegeneration,

Qualifications

• PhD required for position.
• 4-5 years of experience in related research fields.
• Experience with human iPSC-based brain models and omics approaches.

Responsibilities

• Study genetic and environmental factors shaping brain vulnerability to neurodegenerative disease.
• Develop and apply human iPSC-based brain models including organoids and assembloids.
• Integrate genomic, computational, and systems-level approaches to understand disease processes.

Skills

Genetic risk mechanisms

Neurodegeneration research

iPSC brain models

Brain organoid engineering

Multi-omics analysis

Neurovascular & glial biology

Education

PhD

Tools

iPSC models

Organoid/assembloid engineering

Post-mortem brain analysis

Mouse models

Job description

Description

Salary: $74,692.00

Department: Stem Cell Biology & Regenerative Medicine

Physical work location: 619 West 54th Street, 8th Floor, New York, NY 10019

Name PI or Supervisor: Joel Blanchard, PhD

Web link to Lab: https://labs.icahn.mssm.edu/yinglab/

Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology

Administrative Contact: Stacy Paris / [e-mail]

Responsibilities

Details of Research Project:

The Blanchard Laboratory is seeking highly skilled, creative, and motivated scientists to join our team studying how genetic and environmental factors shape the human brain’s vulnerability to neurodegenerative disease.

Our research focuses on uncovering the cellular and molecular mechanisms underlying Alzheimer’s disease and related neurodegenerative disorders, with the goal of identifying new therapeutic strategies. To accomplish this, the lab develops and applies advanced human iPSC-based brain models, including multicellular organoid and assembloid systems that recapitulate key aspects of human brain biology. These platforms are integrated with genomic, computational, and systems-level approaches to understand how genetic risk factors and environmental exposures drive disease processes.

Qualifications

Technical Duties: (include any protocols)

Projects in the laboratory span multiple areas of neurodegeneration research, including:

• Genetic risk mechanisms in Alzheimer’s disease (e.g., APOE biology)


• Neurovascular and glial contributions to neurodegeneration


• Lipid metabolism and metabolic stress in the aging brain


• Human brain organoid and assembloid engineering


• Multi-omics analysis of human brain tissue and disease models

Our experimental platforms combine human iPSC models, post-mortem human brain analysis, and mouse models, enabling mechanistic discoveries that directly inform translational research.

Educational and other Requirements for the position: PhD

Experience Required: 4-5 years

Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well‑being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.