Postdoctoral Fellow-MSH-30030-280

Mount Sinai; United States; On-site; USD 64,000 - 86,000; Full time

Job summary

Mount Sinai in New York is seeking a Postdoctoral Fellow in Microbiology to study cell biology of viral pathogenesis, focusing on replication dynamics of henipaviruses and related paramyxoviruses.

The successful candidate will apply biochemical and biophysical analyses, use reverse genetics to generate mutants, and help train lab members, with opportunities to develop AI-driven multi-omic approaches and present results at national/international meetings.

Qualifications

• PhD in an immediately relevant field.
• At least TWO first or co-first author publications from graduate work.

Responsibilities

• Apply biochemical and biophysical analysis to paramyxovirus proteins and complexes critical for the life cycle of the virus with emphasis on henipavirus and related viruses.
• Use reverse genetics to generate paramyxoviruses with relevant mutations for structure-function analysis of replication and pathogenesis.
• Perform and teach protein synthesis/production techniques to lab members.
• Partake in rotating lab responsibilities contributing to a well-functioning lab.
• Join in all relevant intellectual activities of the lab and department.
• Proactively apply for eligible fellowships.
• Present work at national and/or international conferences; write and publish results promptly.

Skills

Biochemical analysis

Biophysical analysis

Cell biology

Reverse genetics

Academic writing

Education

PhD in a relevant field

Tools

Reverse genetics

Multi-omic AI tools

Job description

Salary: $74,692 per year

Department: Microbiology

Physical work location: One Gustave L. Levy Place Box #1124, NY, NY 10029

Name PI or Supervisor: Benhur Lee; [e-mail]; 212-241-2552

Web link to Lab: https://leelabvirus.host/

Web link to Dep’t: https://icahn.mssm.edu/about/departments/microbiology

Administrative Contact: Molly Deroy; [e-mail]; 212-241-7318

Details of Research Project:

Cell biology of viral pathogenesis. The postdoctoral fellow’s research will focus on replication dynamics of henipaviruses and/or related (re)emerging paramyxoviruses, including characterizing how pro- and anti-viral host factors modulate the early and late stages of the paramyxovirus life cycle. They will bring a biochemical and biophysical perspective to projects in the lab. They will also help in identifying novel viral and host determinants that modulate viral replication and pathogenesis with the aim of developing strategies that might target these determinants. The postdoc is expected to learn and become proficient in applying AI models to multi-omic analysis to help advance their scientific work and that of the lab in general.

Technical Duties:

• Apply biochemical and biophysical analysis to paramyxovirus proteins and complexes critical for the life cycle of the virus with a special emphasis on henipavirus and (re-)emerging paramyxoviruses.
• Use reverse genetics to generate paramyxoviruses with relevant mutations that allow for structure-function analysis of viral replication, budding, or other virus induced sub-organellar complexes such as inclusion bodies or biomolecular condensates.
• Perform and teach protein synthesis/production techniques to other members of the lab.
• Partake in rotating lab responsibilities that contribute to a well-functioning lab.
• Join in all relevant intellectual activities of the lab and department.
• Proactively apply for eligible fellowships.
• Present his work at national and/or international conferences in consultation with the PI.
• Write and publish results in a timely fashion.

Educational and other Requirements for the position: (1)PhD in an immediately relevant field. (2) At least TWO first or co-first author publications from graduate work.

Experience Required: Research experience preferred, but less than 9 months since defending PhD.