Postdoctoral Fellow-MSH-30020-173

Mount Sinai; United States; Vor Ort; USD 75.000 - 80.000; Vollzeit

Zusammenfassung

Mount Sinai is seeking a highly skilled scientist to study how genetic and environmental factors shape neurodegeneration using human iPSC-based brain models, including organoids and assembloids. You will work on Alzheimer's disease mechanisms and related disorders, applying genomic and computational methods to uncover therapeutic insights.

The ideal candidate holds a PhD with several years of postdoctoral or research experience and will contribute to translational projects within the Stem Cell

Qualifikationen

• PhD required.
• 4-5 years of relevant research experience.
• Experience with human iPSC models, organoids or assembloids is a plus.

Aufgaben

• Work on genetic risk mechanisms in Alzheimer’s disease.
• Develop and apply iPSC-based brain models including organoids and assembloids.
• Integrate multi-omics with genomic and computational approaches.
• Collaborate across translational research teams.

Kenntnisse

Genetic risk mechanisms

Neurodegeneration research

Organoid engineering

Multi-omics analysis

Ausbildung

PhD

Jobbeschreibung

Salary: $74,692.00

Department: Stem Cell Biology & Regenerative Medicine

Physical work location: 619 West 54 th Street, 8 th Floor, New York, NY 10019

Name PI or Supervisor: Joel Blanchard, PhD

Web link to Lab: https://labs.icahn.mssm.edu/yinglab/

Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology

Administrative Contact: Stacy Paris / [e-mail]

Details of Research Project:

The Blanchard Laboratory is seeking highly skilled, creative, and motivated scientists to join our team studying how genetic and environmental factors shape the human brain's vulnerability to neurodegenerative disease. Our research focuses on uncovering the cellular and molecular mechanisms underlying Alzheimer's disease and related neurodegenerative disorders, with the goal of identifying new therapeutic strategies. To accomplish this, the lab develops and applies advanced human iPSC-based brain models, including multicellular organoid and assembloid systems that recapitulate key aspects of human brain biology. These platforms are integrated with genomic, computational, and systems-level approaches to understand how genetic risk factors and environmental exposures drive disease processes.

Technical Duties: (include any protocols)

Projects in the laboratory span multiple areas of neurodegeneration research, including:

• Genetic risk mechanisms in Alzheimer's disease (e.g., APOE biology)
• Neurovascular and glial contributions to neurodegeneration
• Lipid metabolism and metabolic stress in the aging brain
• Human brain organoid and assembloid engineering
• Multi-omics analysis of human brain tissue and disease models

Our experimental platforms combine human iPSC models, post-mortem human brain analysis, and mouse models, enabling mechanistic discoveries that directly inform translational research.

Educational and other Requirements for the position

PhD

Experience Required

4-5 years

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,69200 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 865 - Cell Developmental & Regenerative Biology - ISM, Icahn School of Medicine