Postdoctoral Fellow, Leukemia Genomics & Regulatory Biology

Baylor College of Medicine; Houston (TX); Presencial; USD 63 000 - 64 000; Tempo integral

Resumo da oferta

Baylor College of Medicine in Houston, TX, is seeking a Postdoctoral Associate in Leukemia Genomics to lead experimental validation studies integrated with multiomic data and computational analysis.

The role involves training or mentoring students and junior staff as the lab grows, with responsibility for coordinating with cores and clinical workflows to study regulatory genomics and treatment resistance in leukemia.

Qualificações

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Responsabilidades

• Plans, conducts, and analyzes specialized experiments to validate candidate leukemia driver mechanisms nominated from genomic and multiomic data.
• Develops and implements molecular and cell-based assays that includes reporter assays, CRISPR-based perturbation approaches, transcriptional readouts, chromatin-state assays, and molecular validation studies.
• Coordinates experimental design with computational analysis teams, clinical sample workflows, and shared institutional cores.
• Maintains experimental documentation, assay QC records, cell-line records, sample metadata, and reproducible wet-lab protocols.
• Interprets experimental results in the context of patient-derived genomic and multiomic data; prepare figures, reports, abstracts, manuscripts, and presentations.
• Coordinates functional validation of cryptic structural and noncoding regulatory alterations identified from WGS, long-read sequencing, WTS, DNA methylation, ATAC-seq, and HiChIP data.
• Manages cell-line and model-system studies testing candidate regulatory mechanisms using reporter assays, CRISPR-based enhancer or breakpoint perturbation, transcriptional readouts, chromatin-state profiling, and molecular validation assays.
• Manages experimental studies of high-risk leukemia/lymphoma regulatory programs, including subtype-specific transcription factor circuits, enhancer-promoter relationships, and regulatory states associated with treatment resistance or relapse.
• Coordinates wet-lab experiments with computational teams, clinical sample workflows, and shared cores.
• Performs other job-related duties as assigned.

Conhecimentos

Leukemia biology

Cancer genomics

Regulatory genomics

CRISPR perturbation

Sequencing assays

Formação académica

MD or PhD in Basic Science or Health Science

PhD in molecular biology or related field

Ferramentas

CRISPR-based perturbation

Chromatin assays

Molecular cloning

Reporter assays

Descrição da oferta de emprego

Baylor College of Medicine in Houston, TX, is seeking a Postdoctoral Associate in Leukemia Genomics to lead experimental validation studies integrated with multiomic data and computational analysis.

The role involves training or mentoring students and junior staff as the lab grows, with responsibility for coordinating with cores and clinical workflows to study regulatory genomics and treatment resistance in leukemia.