Postdoc: Cancer Genomics for Pediatric Leukemia

Baylor College of Medicine; Houston (TX); On-site; USD 70,000 - 75,000; Full time

Job summary

Baylor College of Medicine in Houston, TX, is seeking a Postdoctoral Associate - Specialist in Cancer Genomics to analyze and interpret large-scale leukemia genomic and multiomic datasets. The role emphasizes WGS, WTS, methylation, long-read sequencing, ATAC-seq, HiChIP, and single-cell data, with an emphasis on variant interpretation and model validation.

The candidate will mentor students or junior analysts as the lab expands, integrating sequencing data, clinical covariates, and biological

Qualifications

• Ph.D. in a quantitative field or related discipline.
• Experience with WGS/WTS, RNA-seq, DNA methylation and multiomic data.
• Strong programming and data analysis skills.
• Ability to work with large pediatric leukemia datasets.

Responsibilities

• Analyze and interpret genomic, transcriptomic, epigenomic, long-read, chromatin-accessibility, chromatin-contact, and single-cell datasets from pediatric leukemia studies.
• Perform variant interpretation, structural variant annotation, subtype classification, fusion/gene-expression analysis, methylation analysis, and multiomic integration.
• Support validation/evaluation of multiomic classifiers and risk models, including benchmarking and documentation of research outputs.
• Participate in testing, documentation, QC review, and implementation of reproducible WGS/WTS workflows.
• Prepare data summaries, figures, reports, manuscripts, and presentations for collaborative research projects.
• Coordinate long-read sequencing and DNA methylation analysis to identify cryptic variants and methylation patterns in leukemia/lymphoma.
• Manage multiomic classifier and risk-model validation against existing diagnostic workflows.

Skills

Genomics data analysis

Multi-omics integration

Data interpretation

Education

Ph.D. in chemistry/computational sciences or related field

Tools

R

Linux/HPC

Version control

Reproducible workflows

Job description

Baylor College of Medicine in Houston, TX, is seeking a Postdoctoral Associate - Specialist in Cancer Genomics to analyze and interpret large-scale leukemia genomic and multiomic datasets. The role emphasizes WGS, WTS, methylation, long-read sequencing, ATAC-seq, HiChIP, and single-cell data, with an emphasis on variant interpretation and model validation.

The candidate will mentor students or junior analysts as the lab expands, integrating sequencing data, clinical covariates, and biological