Postdoctoral Fellow - Feixiong Cheng Lab

Cleveland Clinic; Cleveland (OH); On-site; USD 63,000 - 77,000; Full time

Job summary

Cleveland Clinic is seeking highly motivated Postdoctoral Research Fellows in the Feixiong Cheng Lab at the Cleveland Clinic Main Campus. The fellowship emphasizes experimental and computational approaches to human complex diseases, particularly Alzheimer’s disease and brain health.

Appointments are through Cleveland Clinic Research with NIH NRSA postdoctoral salary support. Ideal candidates hold a PhD or MD/PhD, demonstrate strong communication and collaboration skills, and are prepared to

Qualifications

• Requires PhD or MD/PhD.
• Strong computational skills and knowledge of statistics and mathematics.
• Proficiency in at least one programming language (R, Python, Perl, C++, or Java).
• Proficiency in spoken and written English is required.

Responsibilities

• Conduct experimental or computational research to investigate disease mechanisms and identify diagnostic biomarkers and therapeutic targets.
• Generate or analyze molecular profiling data using omics approaches.
• Apply experimental and computational methods to integrate molecular findings with large-scale patient data.
• Collaborate with physicians, geneticists, and computational/experimental biologists on funded projects.

Skills

Computational skills

English proficiency

Programming languages

Education

PhD or MD/PhD

Tools

R

Python

Perl

C++

Java

Job description

At Cleveland Clinic Health System, we believe in a better future for healthcare. And each of us is responsible for honoring our commitment to excellence, pushing the boundaries and transforming the patient experience, every day.

We all have the power to help, heal and change lives — beginning with our own. That’s the power of the Cleveland Clinic Health System team, and The Power of Every One.

Job Title

Postdoctoral Fellow - Feixiong Cheng Lab

Location

Cleveland

Facility

Cleveland Clinic Main Campus

Department

Job Code

X1004

Shift

Variable

Schedule

12:00am-12:00am

Job Summary

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Compensation follows the NIH NRSA Postdoctoral Salary Scale based on total years of postdoctoral experience.

Job Details

NIH NRSA Postdoctoral Salary Scale

Years of Experience: Stipend for FY 2026

0: $63,480

1: $63,900

2: $64,380

3: $66,948

4: $69,180

5: $71,748

6: $74,424

7 or More: $77,076

The Cheng Lab and Cleveland Clinic Genome Center seek highly motivated Postdoctoral Research Fellows for experimental and computational research focused on human complex diseases, particularly Alzheimer’s disease and brain health. Fellows will join institutionally and federally funded projects and collaborate with investigators across Cleveland Clinic and Case Western Reserve University. Computational applicants should hold a PhD or MD in bioinformatics, genome science, systems biology, biomedical informatics, computational biology, machine learning, data science, drug discovery, or a related field. Strong computational skills, proficiency in at least one programming language such as R, Python, Perl, C++, or Java, and knowledge of statistics and mathematics are required for computational positions. Proficiency in spoken and written English is required for all candidates. Positions are available immediately. Applications will be considered until December 31, 2026, or until the positions are filled.

Principal Investigator: Feixiong Cheng, PhD

Cleveland Clinic Research Department: Genome Center, Genomic Sciences and Systems Biology

Lab Research Topics:

• Alzheimer’s disease and brain health
• Functional genomics and multi-omics
• Artificial intelligence and computational biology
• Network medicine and systems biology
• Precision medicine and drug discovery

For more information about the lab’s research, please visit: https://www.lerner.ccf.org/genomics-research/ or contact William Martin at [e-mail]

Responsibilities:

• Conduct experimental or computational research to investigate disease mechanisms and identify diagnostic biomarkers and therapeutic targets.
• Generate or analyze molecular profiling data using functional genomics, transcriptomics, proteomics, metabolomics, or related approaches.
• Apply experimental models or computational methods to integrate molecular findings with large-scale patient data.
• Collaborate with physicians, geneticists, and computational and experimental biologists on institutionally and federally funded projects.

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting. Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• For experimental candidates, experience with CRISPR, Prime editing, and functional genomics.
• For experimental candidates, experience with patient-derived iPSC neuronal, microglial, or astrocyte models and brain organoids.
• For computational candidates, experience with machine learning, deep learning, foundation models, and high-performance computing.
• Experience analyzing large-scale genomic datasets, including bulk and single-cell or single-nucleus DNA or RNA sequencing.
• Knowledge of genetics, genomics, cell signaling, gene regulatory networks, and protein-protein interaction networks.

Physical Requirements:

• Ability to perform work in a stationary position for extended periods
• Ability to operate a computer and other office equipment
• Ability to communicate and exchange accurate information
• Ability to distinguish color
• Manual dexterity to handle specimens and repair equipment
• Ability to lift and transport equipment or specimens weighing up to 20 pounds
• May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

• Cover letter describing research experience and skills.
• Research statement and plan, 2 to 3 pages.
• Curriculum vitae.
• Contact information for three references.

Keywords:

Postdoc, CRISPRi, Prime Editing, iPSC, Brain Organoids,TOPMed, TCGA, ICGC, GTEx, 1000 Genomes, UK Biobank, ENCODE, ExAC, PDB, radiomics, interactomics, electronic health records

The policy of Cleveland Clinic Health System and its system hospitals (Cleveland Clinic Health System) is to provide equal opportunity to all of our caregivers and applicants for employment in our drug free environment. All offers of employment are followed by testing for controlled substances.

Cleveland Clinic Health System administers an influenza prevention program. You will be required to comply with this program, which will include obtaining an influenza vaccination on an annual basis or obtaining an approved exemption.

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Cleveland Clinic is pleased to be an equal employment opportunity employer.