Postdoctoral Fellow-Discovery Protein Science

Initial Therapeutics, Inc.; South San Francisco (CA); On-site; USD 90,000 - 110,000; Full time

Benefits offered by this job

Comprehensive employee benefits package

Discretionary annual bonus program

Stock-based long-term incentives

Award-winning time-off plans

Flexible work models where possible

Job summary

Initial Therapeutics, Inc. is seeking a Postdoctoral Fellow for Discovery Protein Science in South San Francisco. You will construct protein libraries for autoantigen profiling and collaborate across various scientific teams to advance drug discovery.

The ideal candidate has a PhD and demonstrates independent research skills, with a passion for teamwork in a collaborative setting. This role is fundamental in developing impactful methodologies and includes a competitive salary and benefits.

Qualifications

• PhD at the time of appointment in a relevant field.
• Proven experience in designing and interpreting experiments.
• Experience with mammalian cell culture is a plus.

Responsibilities

• Construct and validate protein libraries for autoantigen profiling.
• Apply libraries to profile antibody binding.
• Collaborate with cross-functional scientists.

Skills

Independent design and execution of experiments

Excellent critical thinking

Communication skills

Collaboration within teams

Education

PhD in molecular biology, chemical biology, biochemistry, or related life sciences

Tools

Protein library construction

Flow cytometry

NGS analysis workflows

Job description

Postdoctoral Fellow-Discovery Protein Science

What you will do

Lets do this! Lets change the world.

The integrative Protein Generation and Protein Design groups within Discovery Protein Science are seeking a highly motivated and creative scientist to develop impactful platforms toward advancing new therapeutic hypotheses. In this vital role, you will apply interdisciplinary approaches to develop methodologies for autoantigen profiling, with implications for target identification and biomarker discovery.

This is a 4-year fellowship within Amgen's Research & Development Postdoc Program, dedicated to training the next generation of biomedical scientists. It is an onsite laboratory position at our South San Francisco site. To support your research, you will have access to state‑of‑the‑art molecular biology, protein design, protein expression, protein biochemistry, and flow cytometry capabilities.

Responsibilities

• Construct and validate protein libraries for autoantigen profiling
• Apply generated libraries to profile the binding of complex mixtures of antibodies
• Interact and collaborate with scientists cross‑functionally, gaining broad exposure to the process of drug discovery
• Make novel discoveries that contribute to the broader field, disseminating scientific contributions through impactful publications and conference presentations

Basic qualifications

• Ph D at the time of appointment in molecular biology, chemical biology, biochemistry, or related life science disciplines

Preferred qualifications

• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first‑author publication(s)
• Proven experience in sequence and structure‑based construct design to improve protein expression and high‑efficiency cloning methods
• Experience with protein library construction, mammalian cell culture, flow cytometry, and NGS analysis workflows is a plus
• Excellent critical thinking, organizational, and communication skills
• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

What you can expect from us

From our competitive benefits to our collaborative culture, we support your professional and personal growth and well‑being. We will work to care for your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is $100,000.

Benefits

• A comprehensive employee benefits package, including a retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.