Postdoctoral Fellow, Chemistry

PeopleAdmin, Inc.; Bloomington (IN); On-site; USD 48,000 - 57,000; Full time

Job summary

The Lewis Lab in the Department of Chemistry at Indiana University is accepting applications for a Postdoctoral Fellow position to develop cutting-edge protein engineering techniques for new chemical transformations.

You will combine organic chemistry with state-of-the-art methods in directed evolution, sequencing, and laboratory automation to create novel B12-dependent enzymes and metalloenzymes with diverse cofactors.

Qualifications

• PhD in chemistry or biochemistry required.
• Experience with molecular biology or synthetic chemistry is strongly preferred.
• Strong documentation and communication skills are essential.

Responsibilities

• Cloning and other molecular biology tasks for enzyme production and engineering.
• Synthesis of substrates and product standards.
• High-throughput screening of enzyme libraries.
• Application of computational protein design tools and data analysis.

Skills

Molecular biology

Synthetic chemistry

Protein engineering

Computational design tools

Education

PhD in chemistry or biochemistry

Job description

The Department of Chemistry in the College of Arts + Sciences at Indiana University consists of a well‑rounded research community with cutting‑edge expertise in a wide variety of modern disciplines—including analytical chemistry, organic chemistry, inorganic chemistry, physical chemistry, materials chemistry, and biochemistry.

Indiana University is an equal employment and affirmative action employer and a provider of ADA services and prohibits discrimination in hiring.

See Indiana University Notice of Non-Discrimination here which includes contact information.

Job Summary

The Lewis Lab in the Department of Chemistry at Indiana University is accepting applications for a Postdoctoral Fellow position. The position offers an opportunity to develop and apply cutting‑edge protein engineering techniques to address fundamental challenges in synthetic chemistry and biocatalysis. The successful applicant will use a deep understanding of organic and organometallic chemistry, combined with state‑of‑the‑art methods generative protein design, directed evolution, next‑gen sequencing, and laboratory automation to develop B12‑dependent enzymes or artificial metalloenzymes containing different organometallic cofactors for new chemical transformations. Motivated applicants with PhD training in any area of chemistry or biochemistry will be considered. Experience with either molecular biology or synthetic chemistry is strongly preferred.

Responsibilities

Primary research responsibilities will include cloning and other molecular biology required for enzyme production and engineering, synthesis of substrates and product standards, high‑throughput screening of enzyme libraries, and application of computational protein design tools. Careful documentation of all findings, formal research reports and presentations, and participation in group equipment/facility maintenance is also expected.

Required Qualifications

Candidates must have extensive experience with either molecular biology or synthetic chemistry. PhD in any area of chemistry or biochemistry.

Preferred Qualifications

Experience with both molecular biology and synthetic chemistry is preferred but not required. Familiarity with computational design tools, organometallic catalysis/methodology development, enzyme library generation and screening are highly desirable.

Department Contact

The initial appointment for this position will be for 12 months. Additional 12-month extension will be available based on performance. A competitive salary along with a benefits package will be offered.

Prof. Lewis, Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, [e-mail].

For additional information visit:

https://lewis.lab.indiana.edu/

Required Documents

• Curriculum Vitae
• Letter of Application
• Letter of Reference 1
• Letter of Reference 2
• Letter of Reference 3
• List Of References

Best consideration date: 07/21/2026.

Expected start date: 10/01/2026.