Postdoctoral Biophysics Scientist - AI-Driven Drug Discovery

BioSpace; Indianapolis (IN); On-site; USD 58,000 - 123,000; Full time

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Life insurance

Leave benefits

Well-being programs

Job summary

Lilly in Indianapolis, Indiana, is seeking a Postdoctoral Biophysical Chemist to join a cross-functional team supporting Early Molecule Discovery. You will combine biophysical NMR, quantum calculations, molecular dynamics, and AI/ ML to study protein motion and protein-ligand interactions for structure-based drug design.

The role is onsite in Indianapolis, up to 2 years, with emphasis on collaboration, data interpretation, and presenting results to internal and external teams.

Qualifications

• PhD required in Biophysical Chemistry, Biophysics, Computational Chemistry, or related field.
• Strong foundation in biomolecular NMR with expertise in protein structure and dynamics.
• Demonstrated experience integrating experimental data with molecular dynamics.
• Authorized to work in the United States on a full-time basis.

Responsibilities

• Execute biophysical and biomolecular NMR experiments to explore biomolecular energy landscapes and conformations.
• Integrate experimental data with quantum mechanical calculations, molecular dynamics simulations and free energy calculations to study protein motion, protein-ligand interactions, and protein-protein interactions in support of structure-based drug design.
• Develop and implement novel AI and neural networks for analyzing experimental and molecular dynamics simulations into integrated structural models.
• Script and automate workflows across computational software platforms to maximize throughput and reproducibility of molecular calculations.
• Stay current with emerging methods in computational drug discovery, including AI and machine learning models for ligand binding and model building.
• Maintain critical timelines and communicate progress clearly through oral and written presentations at internal and external team meetings.
• Collaborate with discovery scientists to advance portfolio molecules from leads to quality drug candidates.

Skills

Biophysical NMR

Biophysics

Computational chemistry

Python

AI/ML in drug discovery

Molecular dynamics

Cloud computing

Education

Ph.D. in Biophysical Chemistry, Biophysics, Computational Chemistry, or related field

Tools

HPC clusters

Gromacs/AMBER

Python

Cloud computing

Job description

Lilly in Indianapolis, Indiana, is seeking a Postdoctoral Biophysical Chemist to join a cross-functional team supporting Early Molecule Discovery. You will combine biophysical NMR, quantum calculations, molecular dynamics, and AI/ ML to study protein motion and protein-ligand interactions for structure-based drug design.

The role is onsite in Indianapolis, up to 2 years, with emphasis on collaboration, data interpretation, and presenting results to internal and external teams.