Postdoctoral Associate | Sickle Cell Disease | Agoro Lab

thejacksonlaboratory; Bar Harbor (ME); On-site; USD 66,000 - 76,000; Full time

Job summary

The Jackson Laboratory in Bar Harbor, ME invites applications for a Postdoctoral Associate in Sickle Cell Disease. You will pioneer the development of mouse models and analyze patient-derived data to understand disease phenotypic heterogeneity, using CRISPR-based tools and single-cell multi-omics.

Ideal candidates have a strong molecular biology background and experience with high-throughput genomics; collaboration across JAX labs and external partners is encouraged.

Qualifications

• Ph.D. in cell biology, molecular biology, genetics, or related field.
• Strong training in molecular biology, cell biology, and next‑gen sequencing.
• Experience with computational biology, genetic screens and single‑cell technologies preferred.
• At least one first-author publication in a peer‑reviewed journal.
• Excellent writing and communication skills; ability to work independently.

Responsibilities

• Develop mouse models that recapitulate disease phenotypes.
• Work with data from sickle cell disease patients and collaborators.
• Apply cutting‑edge technologies (CRISPR, single‑cell multi‑omics) to research questions.
• Collaborate with internal and external translational scientists and clinicians.

Skills

Communication

Independent work

Writing skills

Collaboration

Education

Ph.D. in cell biology / molecular biology / genetics

Tools

CRISPR technologies

Single-cell sequencing

Genetic screens

Job description

Postdoctoral Associate | Sickle Cell Disease

Agoro Lab

Bar Harbor, ME

The Agoro lab at the Jackson Laboratory for Mammalian Genetics is seeking a highly motivated postdoctoral fellow to identify mechanisms that trigger sickle cell disease crisis. The goal of our laboratory is to determine the mechanisms of disease severity heterogeneity using systems biology. We use a multidisciplinary approach that integrates genetics, genomics, proteomics, and metabolomics to isolate systemic and tissue-specific marker of disease progression.

The ideal candidate would have a strong background in molecular biology, and genomic technologies. Exceptional candidates can show early independence through the JAX Scholars Program. The selected candidate will have the opportunity to collaborate with other laboratories within the JAX community and with external collaborators who are translational scientists and clinicians.

As a postdoctoral scientist in our lab, you will pioneer the development of new mouse models that recapitulate disease phenotypic heterogeneity as seen in patients. You will work with data generated from sickle cell disease patients. In our group, you will apply a broad range of cutting‑edge technologies, including CRISPR‑based tools, single‑cell multi‑omics, and create new disease mouse models that better recapitulate disease phenotype.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its research excellence, unparalleled mouse resources, state of the art facilities for computational science, mass spectrometry, imaging science, genome technologies, outstanding training environment characterized by scientific collaborations, and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. In addition to lab‑based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

Qualifications

• Ph.D. in cell biology, molecular biology, genetics, or related field of study.
• Strong training background in molecular biology, cell biology, next‑generation sequencing technology.
• Experience in computational biology, genetic screens and single‑cell technologies are particularly preferred.
• Candidates should have at least one 1st author publication record in peer‑reviewed journal.
• Excellent writing and communication skills, able to work independently and effectively with other members in a productive team.

We are an inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork.

JAX Salary

Year 0 - 1 $65,589
Year 1 - 2 $67,318
Year 2 - 3 $69,095
Year 3 - 4 $70,521
Year 4 - 5 $72,877
Year 5 - 6 $75,569

Based on years of experience as Postdoc

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.