Postdoctoral Associate, Physiology and Biophysics

University at Buffalo; Buffalo (NY); On-site; USD 49,000 - 70,000; Full time

Benefits offered by this job

Visa sponsorship

Job summary

The University at Buffalo invites applications for a Postdoctoral Associate in Physiology and Biophysics. The lab focuses on dynamic molecular mechanisms underlying protein function, integrating structural biology, electrophysiology, quantitative biophysics, and computation to visualize transient events and establish new insights.

Research emphasizes thermoTRP ion channels, time-resolved cryo-EM, and development of innovative techniques.

Qualifications

• Ph.D. in Biochemistry, Biophysics, Structural Biology, Molecular Biology, Neuroscience, Physiology, Biomedical Engineering, Physics or related discipline.
• Experience in electrophysiology, protein biochemistry, structural biology, cryo-EM or fluorescence microscopy desirable.

Responsibilities

• Participate in interdisciplinary research on dynamic protein biophysics and mechanism studies.
• Contribute to time-resolved cryo-EM projects and data analysis.
• Collaborate across structural biology, electrophysiology, and computation to model protein dynamics.

Skills

Electrophysiology

Protein biochemistry

Structural biology

Cryo-EM

Fluorescence microscopy

Computation

Education

PhD in Biochemistry/Biophysics/Structural Biology/Molecular Biology/Neuroscience/Physiology/Biomedical Engineering/Physics

Tools

QuB software

Job description

Postdoctoral Associate, Physiology and Biophysics

Position Title Postdoctoral Associate, Physiology and Biophysics

Postdoctoral Position Available Immediately

Biology happens in motion. Yet most structural and biophysical methods capture only static snapshots. Our laboratory seeks to understand dynamic molecular mechanisms underlying protein function. We integrate structural biology, electrophysiology, quantitative biophysics, and computational approaches to visualize transient molecular events and uncover the physical principles that govern protein function.

Our philosophy is simple: When existing tools cannot answer important biological questions, we build new ones. This has led to innovations ranging from the QuB software suite for single-channel kinetic analysis, to submillisecond temperature-clamp electrophysiology, differential scanning calorimetry for thermal activation, and now time-resolved cryo-EM. Together, these approaches are establishing a new framework for dynamic structural biophysics.

Current Research

Our current biological focus is thermoTRP ion channels – molecular sensors of temperature and pain.

Beyond these fascinating proteins, our long-term goal is to develop broadly applicable approaches for studying protein dynamics across diverse biological systems.

Current research includes:

• Decoding the mechanisms of temperature sensing by ion channels
• Developing and applying time-resolved cryo-EM to capture previously inaccessible conformational states
• Engineering ultrafast perturbation methods that trigger and trap dynamic protein motions in real time.
• Integrating structural, electrophysiological, thermodynamic, and computational approaches into quantitative models of protein dynamics

This position offers the opportunity to participate in an innovative, interdisciplinary research program at the interface of structural biology, electrophysiology, instrumentation, and quantitative biophysics.

Working closely with Professor Qin and collaborators, the successful candidate will contribute to exciting biological discoveries while building a broad foundation in modern structural and biophysical research.

The laboratory emphasizes close mentoring, creativity, interdisciplinary collaboration, and professional development, providing an environment in which trainees progress from guided research to increasing scientific independence while developing their own scientific ideas, learning new techniques, and producing high-quality publications.

We do not expect applicants to have expertise in every aspect of our research. Laboratory members come from diverse backgrounds, including electrophysiology, structural biology, protein biochemistry, computation, physics, and engineering. We build on each individual’s strengths while providing opportunities to broaden their expertise, learn new methodologies, and collaborate across disciplines in a supportive environment.

Professor Qin has over 30 years of mentoring experience and is committed to helping trainees develop into independent scientists through personalized mentoring, scientific freedom, interdisciplinary collaboration, and opportunities to lead innovative research, publish impactful work, and prepare for independent research careers.

Qualifications

Applicants should have, or be close to completing, a Ph.D. in Biochemistry, Biophysics, Structural Biology, Molecular Biology, Neuroscience, Physiology, Biomedical Engineering, Physics, or a related discipline.

Experience in one or more of the following areas is desirable, but not required:

• Electrophysiology
• Protein biochemistry
• Structural biology
• Cryo-EM
• Fluorescent microscopy

Most importantly, we seek motivated, creative, intellectually curious scientists who enjoy tackling important biological problems and are excited to learn new approaches beyond their original area of expertise.

Research Environment

The laboratory provides a highly interdisciplinary environment integrating structural biology, electrophysiology, fluorescence microscopy, protein biochemistry, thermodynamics, instrumentation development, and quantitative modeling.

Our long-standing collaboration with Brookhaven National Laboratory provides access to state-of-the-art cryo-EM facilities and expertise.

Salary, Benefits, and Career Development

This position is available immediately.

Salary is competitive and commensurate with experience following current NIH guidelines.

Working at UB comes with benefits that exceed salary alone. There are personal rewards including comprehensive health and retirement plan options. We also focus on creating and sustaining a healthy mix of work, personal and academic pursuit - all in an effort to support your work-life effectiveness. Visit our benefits website to learn about our benefit packages.

Visa sponsorship is available for qualified international applicants.

About UB

The University at Buffalo is SUNY's most comprehensive public research university, and an outstanding place to work. UB amplifies ambition for faculty and staff by offering endless possibilities to achieve more. Here, people from all backgrounds and cultures challenge and inspire each other to discover, learn and succeed. Dedicated staff and engaged faculty collaborate to further knowledge and understanding, and develop tenacious graduates who are valued for their talents and their impact on global society. Visit our website to learn more about the University at Buffalo: https://www.buffalo.edu

The Research Foundation of SUNY is an EOE and welcomes all to apply including veterans and individuals with a disability.

Preferred Qualifications

• Experience in electrophysiology (patch-clamp), structural biology (single-particle cryo-EM), fluorescence microscopy, or other biophysical approaches for studying protein structure and function.

Our University Community

Physical Demands

Driving Requirements

Driving Requirements This position will never drive a university owned vehicle.

Salary Range

$49,000 – $70,000

Additional Salary Information

The salary range reflects our good faith and reasonable estimate of the possible compensation at the time of posting, the role and associated responsibilities, and the experience, education, and training of the selected candidate.

Work Hours

40 hours per week

Campus

South Campus

Contact Information

• Contact's Name Feng Qin
• Contact's Title
• Contact's Email
• Contact's Phone [phone]

Supplemental Questions

Required fields are indicated with an asterisk (*).

• * How did you first hear about this employment opportunity?
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• * Please indicate your current employment affiliation with the University at Buffalo.
  • Faculty
  • Faculty Student Association (FSA)
  • Research Foundation Employee
  • State Classified
  • State Professional
  • UB Foundation
  • TA/GA
  • Student
  • No Current Employment Affiliation

UB is an AA/EOE and welcomes all to apply including veterans and individuals with disabilities. Arrangements will be made if an applicant has a disability in order to provide access to the application, interview and selection process upon request. Reasonable accommodation requests must be made in a timely manner by email at [e-mail] or by phone [phone].