Postdoctoral Associate - LC-MS-based Omics

Baylor College of Medicine; Houston (TX); On-site; USD 57,000 - 70,000; Full time

Job summary

Baylor College of Medicine in Houston, TX, seeks a highly motivated Postdoctoral Associate for the LC-MS-based Omics division in Pathology. Onsite position with a focus on metabolomics, lipidomics, and drug metabolism using advanced MS platforms.

Extensive training in mass spectrometry, metabolomics, and imaging mass spectrometry awaits. The role emphasizes methodological development, data analysis, and collaboration within a multidisciplinary lab environment, with NIH-like stipend guidelines

Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• PhD or doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry or metabolomics.
• Demonstrated expertise in metabolomics or lipidomics workflows.

Responsibilities

• Develop, optimize and validate LC-MS/LC-MS/MS methods for metabolomics, lipidomics and drug metabolism.
• Prepare and extract metabolites, lipids, drugs from biological matrices.
• Perform untargeted/targeted metabolomics and lipidomics studies.
• Analyze complex MS datasets using computational tools.
• Conduct in vitro drug metabolism studies with liver microsomes and hepatocytes.
• Identify drug metabolites with high-resolution MS/MS.
• Assess cellular toxicity and maintain rigorous experimental records.

Skills

LC-MS metabolomics

Lipidomics

Drug metabolism

MS data analysis

Experimental design

Computational tools

Cell culture basics

Education

MD or PhD in Basic/Health Science

PhD in analytical chemistry/pharmacology/biochem

Tools

Thermo Orbitrap Exploris MS

UHPLC/Q Exactive MS

Imaging mass spectrometry (MALDI/DESI)

Mass spectrometry software

Job description

Job Title: Postdoctoral Associate - LC-MS-based Omics Division: Pathology Work Arrangement: Onsite only Location: Houston, TX Salary Range: $63,480 FLSA Status: Exempt Work Schedule: Monday - Friday, 8 a.m. - 5 p.m.

Requisition ID: 26107

Summary

The Center for Drug Discovery (https://www.bcm.edu/research/centers/drug-discovery) is a strategic research center at Baylor College of Medicine in Houston, Texas. The lab is looking for a highly self-motivated Postdoctoral Research Associate with extensive experience in liquid chromatography-MS metabolomics, lipidomics, and drug metabolism. The Postdoctoral Associate will apply advanced MS-based approaches to study the proteosome and metabolome to characterize our newly created dTAG-KI animal models and conduct the drug metabolism pharmacokinetics studies. The lab is well-equipped with Thermos UHPLC-Q Exactive MS, Orbitrap Exploris 120, Thermo Quintus (triple quadruple), and Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI-2). The position provides opportunities for advanced training in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, and imaging mass spectrometry within a collaborative and multidisciplinary research environment.

Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.

Job Duties

• Develops, optimizes, and validates LC-MS and LC-MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis.
• Performs sample preparation and extraction of metabolites, lipids, drugs, and drug metabolites from cells, tissues, plasma, and other biological matrices.
• Conducts untargeted and targeted metabolomics and lipidomics studies.
• Processes, analyzes, interprets, and visualizes complex mass spectrometry datasets using appropriate computational and statistical tools.
• Performs in vitro drug-metabolism studies that includes incubations with liver microsomes, primary human hepatocytes, and other relevant biological systems.
• Identifies and characterizes drug metabolites using high-resolution mass spectrometry and tandem mass spectrometry.
• Assess cellular toxicity using biochemical, molecular, imaging, and metabolomics-based endpoints.
• Maintains accurate experimental records and contributes to data interpretation, scientific presentations and manuscripts.
• Performs other job-related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• PhD or equivalent doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics, or a related discipline.
• Demonstrated expertise in metabolomics and/or lipidomics, including sample preparation, instrument operation, data processing, and biological interpretation.
• Experience with high-resolution LC-MS platforms, especially Thermo Orbitrap Exploris MS.
• Proficiency with metabolomics and lipidomics data-analysis software and multivariate statistical methods.
• Experience with primary human hepatocytes or other physiologically relevant cell models.
• Experience with imaging mass spectrometry, including MALDI or DESI imaging, would be a significant advantage.
• Experience with mammalian cell culture and drug-induced toxicity studies.
• Strong publication record in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, or related fields.
• Strong organizational, analytical, troubleshooting, and scientific communication skills.

Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.