Postdoctoral Associate - LC-MS-based Omics

Women In Science; Houston (TX); On-site; USD 52,000 - 76,000; Full time

Job summary

The Center for Drug Discovery at Baylor College of Medicine in Houston, TX seeks a highly self‑motivated Postdoctoral Research Associate with extensive LC–MS metabolomics, lipidomics, and drug metabolism experience. The role involves applying advanced MS methods to study proteome and metabolome in newly created dTAG‑KI animal models and to conduct pharmacokinetic studies.

The ideal candidate has a PhD in a related field, strong publication record, and experience with high‑resolution MS platforms

Qualifications

• PhD in a relevant field (analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics).
• Experience with metabolomics and/or lipidomics data analysis.
• Experience with high‑resolution LC–MS platforms such as Orbitrap Exploris MS.

Responsibilities

• Develops, optimizes, and validates LC–MS/LC–MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis.
• Performs sample preparation and extraction from cells, tissues, plasma, and other biological matrices.
• Conducts untargeted and targeted metabolomics and lipidomics studies.
• Analyzes complex MS datasets using computational and statistical tools.
• Performs in vitro drug‑metabolism studies using liver microsomes and primary hepatocytes.
• Identifies and characterizes drug metabolites using high‑resolution MS/MS.
• Assesses cellular toxicity using biochemical, molecular, imaging, and metabolomics endpoints.
• Maintains accurate records and contributes to data interpretation and manuscripts.
• Performs other job‑related duties as assigned.

Skills

Metabolomics

Lipidomics

LC-MS

MS Data Analysis

Cell culture

Imaging MS

Toxicology

Publications

Education

PhD

Analytical chemistry

Biochemistry

Tools

Orbitrap Exploris

MALDI

DESI

Bruker IMS

Job description

Baylor College of Medicine

Houston, TX

Job posting number: #7369302 (Ref:26107-en_US)

Posted: August 25, 2026

Summary

The Center for Drug Discovery ( https://www.bcm.edu/research/centers/drug-discovery) is a strategic research center at Baylor College of Medicine in Houston, Texas. The lab is looking for a highly self‑motivated Postdoctoral Research Associate with extensive experience in liquid chromatography–mass spectrometry (LC–MS) metabolomics, lipidomics, and drug metabolism. The Postdoctoral Associate will apply advanced MS‑based approaches to study the proteosome and metabolome to characterize our newly created dTAG‑KI animal models and conduct the drug metabolism pharmacokinetics studies. The lab is well‑equipped with Thermos UHPLC‑Q Exactive MS, Orbitrap Exploris™ 120, Thermo Quintus (triple quadruple), and Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI‑2). The position provides opportunities for advanced training in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, and imaging mass spectrometry within a collaborative and multidisciplinary research environment. Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.

Job Duties

• Develops, optimizes, and validates LC–MS and LC–MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis.


• Performs sample preparation and extraction of metabolites, lipids, drugs, and drug metabolites from cells, tissues, plasma, and other biological matrices.


• Conducts untargeted and targeted metabolomics and lipidomics studies.


• Processes, analyzes, interprets, and visualizes complex mass spectrometry datasets using appropriate computational and statistical tools.


• Perform in vitro drug‑metabolism studies that includes incubations with liver microsomes, primary human hepatocytes, and other relevant biological systems.


• Identifies and characterizes drug metabolites using high‑resolution mass spectrometry and tandem mass spectrometry.


• Assesses cellular toxicity using biochemical, molecular, imaging, and metabolomics‑based endpoints.


• Maintains accurate experimental records and contributes to data interpretation, scientific presentations and manuscripts.


• Perform other job‑related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.


• No experience required.

Preferred Qualifications

• PhD or equivalent doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics, or a related discipline.


• Demonstrated expertise in metabolomics and/or lipidomics, including sample preparation, instrument operation, data processing, and biological interpretation.


• Experience with high‑resolution LC–MS platforms, especially Thermo Orbitrap Exploris MS.


• Proficiency with metabolomics and lipidomics data‑analysis software and multivariate statistical methods.


• Experience with primary human hepatocytes or other physiologically relevant cell models.


• Experience with imaging mass spectrometry, including MALDI or DESI imaging, would be a significant advantage.


• Experience with mammalian cell culture and drug‑induced toxicity studies.


• Strong publication record in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, or related fields.


• Strong organizational, analytical, troubleshooting, and scientific communication skills.

Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient‑centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.

Contact Information

More Info

Job posting number: #7369302 (Ref:26107-en_US) Application Deadline: Open Until Filled Employer Location: Baylor College of Medicine

Houston, Texas

United States