Postdoctoral Associate

Baylor College of Medicine; Houston (TX); On-site; USD 60,000 - 75,000; Full time

Job summary

Baylor College of Medicine invites applications for a Postdoctoral Associate focused on decoding how infection leaves durable epigenetic and transcriptional scars that shape long term immunity, inflammation, and lung repair.

This position combines single cell transcriptomics and chromatin accessibility, CRISPR-based perturbation, and deeply phenotype human cohorts to define causal mechanisms driving post infectious lung disease.

Qualifications

• MD or PhD in Basic Science, Health Science, or related field.
• No experience required.

Responsibilities

• Implements measurements of inflammation, host immunity, and cellular metabolism from ex vivo samples.
• Implements and analyzes single cell RNA-Sequencing, single cell ATAC-Seq, CITE-Seq, and related datasets.
• Explores organoid models of infection-induced lung disease risk.

Skills

Single-cell analysis

CRISPR perturbation

Bioinformatics

Epigenetics

Immunology

Education

MD or PhD in Basic Science

Tools

scRNA-seq

scATAC-seq

CITE-seq

Perturb-seq

Cut and Run

Job description

Work Schedule: Monday – Friday, 8 a.m. – 5 p.m.

Summary

Baylor College of Medicine invites applications for an innovative and highly interdisciplinary Postdoctoral Associate position focused on decoding how infection leaves durable epigenetic and transcriptional scars that shape long term immunity, inflammation, and lung repair.

This position is ideal for scientists excited to combine single cell transcriptomics and chromatin accessibility, CRISPR based gene and epigenetic perturbation, and deeply phenotype human cohorts to define causal mechanisms driving post infectious and post tuberculosis lung disease.

Postdoctoral Associate will need to implement single cell transcriptomics and epigenomic (scRNA-seq and scATAC, CITE-seq, Perterb-Seq, Cut and Run) on samples collected from participants who have had sepsis, pneumonia, and tuberculosis. Functional/ mechanistic validation of regulatory elements and gene networks controlling inflammation, immune memory, and tissue repair will be implemented using CRISPR inhibition and activation (CRISPRi/a) in primary immune cells and lung organoids. They are expected to be the first author on high-impact manuscripts that can form the basis for K-level or equivalent fellowship applications, or transitions to faculty. The position is optimal for applicants wanting to a) link multi-omic patient results to mechanistic, causal biology; b) eager to integrate wet-lab experiments with advanced bioinformatic analysis; c) excited to work at the interface of human cohorts with robust epidemiologic and long-term outcomes with experimental systems; d) aim to transition to independent investigator roles in academia or industry.

Job Duties

• Implements measurements of inflammation, host immunity, and cellular metabolism from ex vivo PBMCs and plasma from patients recovering from sepsis, pneumonia, or Tuberculosis.
• Implements and analyzes single cell RNA-Sequencing, single cell ATAC-Seq, CITE-Seq, Cut and Run, as well as bulk RNA-Seq, Proteomics, and Metabolomics datasets, generated from pneumonia tuberculosis patient cohorts with rich clinical data.
• Explores organoid models infection induced lung disease risk.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Ph.D. in Biology, Immunology, or similar field, as well as a strong background in statistics.
• Experience in epigenetics or gene regulation is a plus, and experience with statistical analysis tools such as R or Python is recommended.
• Excellent written and verbal English skills, strong communication and interpersonal skills, and be capable of working with large collaborative teams.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.