Postdoc: Single-Cell & Spatial Genomics Analytics Lead

University of Pennsylvania Perelman School of Medicine; Harrisburg (Dauphin County); On-site; USD 60,000 - 75,000; Full time

Job summary

University of Pennsylvania Penn Dental Medicine invites applications for a postdoctoral position in the Graves laboratory to investigate inflammatory mechanisms in diabetes, aging, and related conditions.

The fellow will lead bioinformatic analyses of scRNA-seq and 10x Xenium datasets and validate findings through immunofluorescence and image analysis to map spatial distribution of cell states and adhesion molecules.

Qualifications

• A PhD, MD, DMD, DVM, or equivalent doctoral degree in a relevant field.
• Hands-on experience with bioinformatic analysis of scRNA-seq or spatial transcriptomic data.
• Strong proficiency in R or Python and modern single-cell analysis workflows.
• Ability to work independently and collaborate across disciplines.
• Strong scientific writing and communication skills.

Responsibilities

• Lead bioinformatic analyses of scRNA-seq and 10x Genomics Xenium spatial transcriptomic datasets.
• Serve as project leader for quantitative image analysis of in vivo specimens to characterize the spatial distribution, cellular localization, and tissue organization of adhesion molecules.
• Develop rigorous, reproducible computational workflows.
• Perform quality control, data integration, cell annotation, and differential expression analyses.
• Conduct pathway, trajectory, state-transition, and ligand-receptor analyses.
• Integrate multiomic, cross-species, and cross-cohort datasets.
• Integrate transcriptomic data with imaging, histologic, and phenotypic measurements.
• Generate clear figures and communicate findings to collaborators.
• Contribute to analytical strategy and biological interpretation.
• Present findings and prepare first-author manuscripts.
• Contribute to grant development and collaborative studies.

Skills

Bioinformatics

R/Python

Independent work

Scientific writing

Education

PhD or equivalent doctoral degree

Tools

Seurat

Spatial genomics tools

Job description

University of Pennsylvania Penn Dental Medicine invites applications for a postdoctoral position in the Graves laboratory to investigate inflammatory mechanisms in diabetes, aging, and related conditions.

The fellow will lead bioinformatic analyses of scRNA-seq and 10x Xenium datasets and validate findings through immunofluorescence and image analysis to map spatial distribution of cell states and adhesion molecules.