Postdoc Research Fellow — RNA Virus Replication Mechanisms

The University of North Carolina at Chapel Hill; Chapel Hill (NC); On-site; USD 52,000 - 68,000; Full time

Job summary

The Cameron-Arnold laboratory at the University of North Carolina School of Medicine in Chapel Hill seeks a highly motivated Post-Doctoral Research Associate to study the biochemical and biophysical mechanisms of RNA virus genome replication. The role emphasizes enzymology of RNA-dependent RNA polymerases, ATPases, helicases, and replication complexes.

The successful candidate will explore initiation, elongation, fidelity, and RNA transcription regulation using quantitative enzymology, protein

Qualifications

• PhD required in Biochemistry, Biophysics, Chemistry, Molecular Biology, or closely related field.
• Experience in protein biochemistry, enzymology, molecular biophysics, or mechanistic studies of protein-nucleic acid interactions desirable.
• Experience with recombinant protein expression and purification, quantitative enzyme kinetics, fluorescence spectroscopy or biophysical characterization is valuable.

Responsibilities

• Investigate biochemical and biophysical mechanisms of RNA virus genome replication.
• Define molecular mechanisms of viral RNA synthesis: initiation, elongation, fidelity, recombination.
• Characterize viral ATPases and helicases and multiprotein replication complex function.
• Develop mechanistic projects and pursue interdisciplinary collaboration.

Skills

Molecular biology

Biochemistry

Biophysics

Quantitative enzymology

Education

PhD in Biochemistry, Biophysics, Chemistry, Molecular Biology, or closely related discipline

Job description

The Cameron-Arnold laboratory at the University of North Carolina School of Medicine in Chapel Hill seeks a highly motivated Post-Doctoral Research Associate to study the biochemical and biophysical mechanisms of RNA virus genome replication. The role emphasizes enzymology of RNA-dependent RNA polymerases, ATPases, helicases, and replication complexes.

The successful candidate will explore initiation, elongation, fidelity, and RNA transcription regulation using quantitative enzymology, protein