Postdoc: Protein Interaction & Structure Prediction

Lawrence Livermore National Laboratory; Livermore (CA); Hybrid; USD 122,000 - 143,000; Full time

Benefits offered by this job

Relocation Assistance

Education Reimbursement Program

Flexible schedules

401(k)

Job summary

Lawrence Livermore National Laboratory (LLNL) invites applications for a Postdoctoral Researcher to advance computational structural biology and predict protein-protein interactions in host-pathogen systems. Work includes leveraging RoseTTAFold3, AlphaFold3, and ESMFold2 with large sequence datasets, building novel approaches, and publishing results.

You will join an interdisciplinary team, present findings, and occasionally travel to collaborate with external partners.

Qualifications

• PhD in Life Sciences, Computational Biology, Bioinformatics, or a related technical or scientific field.
• Experience with protein sequence and structure.
• Strong knowledge and research experience in bioinformatics and protein structure modeling.
• Ability to work independently on defined research projects and collaborate in a diverse team.
• Programming experience with Python; proficient in UNIX and HPC environments.
• Ability to publish peer‑reviewed research.
• Ability to travel as necessary.

Responsibilities

• Conduct research and design sequence/structure based bioinformatic tools for protein-protein interaction predictions.
• Interpret biological systems through protein structure prediction.
• Develop computational frameworks and analysis tools for sequence/structure data.
• Create structure-based distillation datasets to aid ML model development.
• Collaborate with external partners (universities, industry, other labs) to advance simulations.
• Prepare progress reports, analyses, and briefings for sponsors.

Skills

Python programming

UNIX/HPC

Bioinformatics

Protein structure modeling

Independent research

Travel willingness

Education

PhD in Life Sciences / Computational Biology / Bioinformatics

Tools

RoseTTAFold3

AlphaFold3

ESMFold2

Job description

Lawrence Livermore National Laboratory (LLNL) invites applications for a Postdoctoral Researcher to advance computational structural biology and predict protein-protein interactions in host-pathogen systems. Work includes leveraging RoseTTAFold3, AlphaFold3, and ESMFold2 with large sequence datasets, building novel approaches, and publishing results.

You will join an interdisciplinary team, present findings, and occasionally travel to collaborate with external partners.