Postdoc: Neurodegeneration Drug Discovery in iPSC Models

BioSpace; Louisville (CO); On-site; USD 58,000 - 123,000; Full time

Job summary

Lilly in Louisville, Colorado, is seeking a motivated postdoctoral scientist to join our small molecule molecular pharmacology team. You will build and interrogate human iPSC-derived neuronal model systems to define the mechanism of action of novel inhibitors in neurodegeneration.

You will design high-content imaging experiments, develop quantitative analyses, and collaborate with leading scientists across biology and chemistry.

Qualifications

• PhD in neuroscience, pharmacology, cell biology, molecular biology, stem cell biology, or closely related life science, with all requirements completed by January 2027.
• Authorized to work in the United States full-time; Lilly will not provide visa sponsorship.

Responsibilities

• Establish and apply human iPSC-derived neuronal models for pharmacology platforms.
• Design high-content imaging experiments to determine mechanism of action for small molecule inhibitors.
• Develop quantitative, multiparametric analyses from imaging and phenotypic data.
• Design novel approaches for small molecule drug discovery in neurodegeneration.
• Collaborate with senior molecular pharmacologists, structural biologists, computational scientists, stem cell biologists, and medicinal chemists.

Skills

iPSC-derived neurons

neuroscience

high content imaging

computational biology

cell culture

Python/R

genome editing

data analysis

publication track record

Education

PhD in neuroscience or related life science

Tools

CellProfiler

Fiji/ImageJ

Harmony

Columbus

GraphPad Prism

PyMOL

MOE

Job description

Lilly in Louisville, Colorado, is seeking a motivated postdoctoral scientist to join our small molecule molecular pharmacology team. You will build and interrogate human iPSC-derived neuronal model systems to define the mechanism of action of novel inhibitors in neurodegeneration.

You will design high-content imaging experiments, develop quantitative analyses, and collaborate with leading scientists across biology and chemistry.