Postdoc in Drug Metabolism, DNA Adducts & Carcinogenesis

Oak Ridge Institute for Science and Education; Arkansas; On-site; USD 27,900 - 43,524; Full time

Benefits offered by this job

Monthly stipend

Job summary

Oak Ridge Institute for Science and Education (ORISE) invites applications for the ORISE Research Fellowship with the FDA‑NCTR in Jefferson, Arkansas. The focus is on nitrosamine drug substance‑related impurities (NDSRIs), mutagenicity, and carcinogenicity using in vitro systems and mammalian cell models.

The fellowship offers hands‑on training in mechanistic study design, experimental execution, and systematic evaluation in drug metabolism and chemical carcinogenesis, with opportunities to

Qualifications

• Doctoral degree in Chemistry, Materials Sciences, or related disciplines (received within last five years or anticipated by 12/31/2026).
• Strong background in chemical analysis, toxicology, or drug metabolism.

Responsibilities

• In vitro metabolism studies using liver S9 fractions, microsomes, and mammalian cell culture systems.
• Characterization of metabolites using HPLC‑UV, LC‑MS/MS, and 1H‑NMR.
• Identification and quantification of DNA adducts formed by NDSRIs in S9/microsomal incubations with DNA and in cell culture systems using 1H‑NMR and LC‑MS/MS.
• Presentation of findings at scientific conferences and publication in peer‑reviewed journals.

Skills

Chemical analysis

Toxicology

Drug metabolism

Education

Doctoral degree in Chemistry

Chemistry or Materials Sciences

Job description

Oak Ridge Institute for Science and Education (ORISE) invites applications for the ORISE Research Fellowship with the FDA‑NCTR in Jefferson, Arkansas. The focus is on nitrosamine drug substance‑related impurities (NDSRIs), mutagenicity, and carcinogenicity using in vitro systems and mammalian cell models.

The fellowship offers hands‑on training in mechanistic study design, experimental execution, and systematic evaluation in drug metabolism and chemical carcinogenesis, with opportunities to