Postdoc: Host-Microbiome & Gut-on-Chip Research

The Jackson Laboratory; Farmington (CT); On-site; USD 66,000 - 76,000; Full time

Job summary

The Jackson Laboratory in Farmington, CT, seeks a highly motivated postdoctoral fellow to study how gut bacteria interact with patient-derived epithelial tissues, shaping cellular states and disease susceptibility. Colorectal cancer will be a primary model, with organoid- and chip-based approaches to explore host-microbiome dynamics.

Ideal candidates have organ-on-a-chip or microfluidics experience and a track record in GI biology, cancer biology, or epithelial plasticity, plus strong molecular

Qualifications

• Ph.D. in bioengineering, microbiology, cell biology, cancer biology, or related field.
• Hands-on experience in cell and tissue engineering and 3D organoid culture.
• Experience with organ-on-a-chip technologies, microfluidics, and host-microbiome coculture is highly desirable.
• Strong background in microscopy, immunofluorescence, gene-expression analysis and functional assays.
• Experience in GI biology, host-microbiome interactions, cancer biology, epithelial plasticity, or aging is preferred.
• At least one first-author publication in a peer-reviewed journal.
• Excellent writing and communication skills; ability to work independently and in teams.

Responsibilities

• Establish and maintain patient-derived intestinal organoids, including nonmalignant and colorectal cancer tissues.
• Integrate organoid epithelia into advanced microphysiological gut-on-a-chip models.
• Design and conduct controlled bacterial-epithelial coculture experiments.
• Apply microscopy, gene-expression analysis, and quantitative functional assays to study epithelial states and functions.
• Integrate functional studies with transcriptomic and other profiling approaches; contribute to publications and collaborative projects.

Skills

Organoid culture

Organ-on-a-chip

Microfluidics

Bacterial coculture

Cellular and molecular biology

Microscopy

Immunofluorescence

Gene-expression analysis

Transcriptomics

Scientific writing

Independent work

Education

Ph.D. in bioengineering, microbiology, cell & molecular biology, cancer biology, or related field

Tools

Organ-on-a-chip

Microfluidics

Transcriptomics

Job description

The Jackson Laboratory in Farmington, CT, seeks a highly motivated postdoctoral fellow to study how gut bacteria interact with patient-derived epithelial tissues, shaping cellular states and disease susceptibility. Colorectal cancer will be a primary model, with organoid- and chip-based approaches to explore host-microbiome dynamics.

Ideal candidates have organ-on-a-chip or microfluidics experience and a track record in GI biology, cancer biology, or epithelial plasticity, plus strong molecular