Postdoc: Endogenous Biomarkers & Translational ADME

Pfizer; Groton (CT); Vor Ort; USD 65.000 - 108.000; Vollzeit

Benefits dieser Stelle

401(k) with company matching

Paid time off

Parental leave

Health benefits

Zusammenfassung

Pfizer is seeking a highly motivated Postdoctoral Fellow to advance discovery and clinical translation of endogenous biomarkers of cytochrome P450 enzymes. The role includes validating biomarkers for CYP inhibition/induction to predict drug-drug interactions and guide clinical decisions.

The successful candidate will lead experimental and analytical research, integrating clinical biomarker analysis, multiplex LC-MS/MS bioanalysis, mechanistic ADME studies, PK data analysis, and PBPK modeling to

Qualifikationen

• PhD in pharmaceutical sciences, pharmacology, pharmacokinetics, drug metabolism, analytical chemistry, biochemistry, biomedical sciences, chemical biology, quantitative pharmacology, or a closely related discipline.
• Relevant hands-on research experience in bioanalysis, in vitro drug metabolism, membrane transporter research, or another experimental area directly related to mechanistic ADME.
• Demonstrated experience designing, conducting, analyzing, and interpreting hypothesis-driven research.

Aufgaben

• Evaluate candidate biomarkers across diverse clinical datasets and investigate factors that influence performance.
• Determine how metabolic enzymes, transporters, renal and biliary clearance, and enterohepatic processes influence biomarker disposition.
• Identify and mechanistically explain variability or discordance among candidate biomarkers.
• Develop a quantitative relationship between endogenous biomarker responses and changes in PK of sensitive CYP substrates.
• Advance the scientific foundation for incorporating endogenous biomarkers into clinical DDI assessment and drug-development decisions.
• Develop expertise across bioanalysis, mechanistic ADME, clinical pharmacology, quantitative modeling, and scientific communication.

Kenntnisse

Scientific writing

Cross-disciplinary collaboration

Data analysis

Ausbildung

PhD in pharmaceutical sciences or related

Tools

LC-MS/MS

R/Python

PBPK modeling

Jobbeschreibung

Pfizer is seeking a highly motivated Postdoctoral Fellow to advance discovery and clinical translation of endogenous biomarkers of cytochrome P450 enzymes. The role includes validating biomarkers for CYP inhibition/induction to predict drug-drug interactions and guide clinical decisions.

The successful candidate will lead experimental and analytical research, integrating clinical biomarker analysis, multiplex LC-MS/MS bioanalysis, mechanistic ADME studies, PK data analysis, and PBPK modeling to