Postdoc: Endogenous Biomarkers & Translational ADME

Pfizer

Groton (CT)

In loco

USD 65.000 - 108.000

Tempo pieno

14 giorni+

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Vantaggi offerti da questo lavoro

401(k) with company matching

Paid time off

Parental leave

Health benefits

Descrizione del lavoro

Pfizer is seeking a highly motivated Postdoctoral Fellow to advance discovery and clinical translation of endogenous biomarkers of cytochrome P450 enzymes. The role includes validating biomarkers for CYP inhibition/induction to predict drug-drug interactions and guide clinical decisions.

The successful candidate will lead experimental and analytical research, integrating clinical biomarker analysis, multiplex LC-MS/MS bioanalysis, mechanistic ADME studies, PK data analysis, and PBPK modeling to

Competenze

PhD in pharmaceutical sciences, pharmacology, pharmacokinetics, drug metabolism, analytical chemistry, biochemistry, biomedical sciences, chemical biology, quantitative pharmacology, or a closely related discipline.
Relevant hands-on research experience in bioanalysis, in vitro drug metabolism, membrane transporter research, or another experimental area directly related to mechanistic ADME.
Demonstrated experience designing, conducting, analyzing, and interpreting hypothesis-driven research.

Mansioni

Evaluate candidate biomarkers across diverse clinical datasets and investigate factors that influence performance.
Determine how metabolic enzymes, transporters, renal and biliary clearance, and enterohepatic processes influence biomarker disposition.
Identify and mechanistically explain variability or discordance among candidate biomarkers.
Develop a quantitative relationship between endogenous biomarker responses and changes in PK of sensitive CYP substrates.
Advance the scientific foundation for incorporating endogenous biomarkers into clinical DDI assessment and drug-development decisions.
Develop expertise across bioanalysis, mechanistic ADME, clinical pharmacology, quantitative modeling, and scientific communication.