Postdoc, Bioorganic Chemistry & Bioconjugation

Los Alamos National Security LLC; Los Alamos (NM); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) with match

Tuition assistance

Paid time off

Job summary

Los Alamos National Laboratory in Los Alamos, NM seeks a Ph.D.-level scientist in chemistry/chemical biology to contribute to a multifaceted B-TEK research program focused on bioorganic synthesis and biomolecule modification.

You will design and synthesize bio‑molecular systems, develop immobilization strategies, and create quantitative assays while collaborating across LANL and with external partners.

Qualifications

• Ph.D. in chemistry, chemical biology, biochemistry, or closely related field completed within the last five years or to be completed within six months
• Expertise in chemical biology, bioorganic chemistry, or a closely related discipline relevant to B-TEK's research mission
• Demonstrated hands-on experience with site-selective peptide or protein modification, bioconjugation, post-translational modifications, or polymer and surface functionalization
• Experience designing and executing multistep syntheses, purification, and characterization
• Experience developing quantitative assays with appropriate controls, calibration, reproducibility criteria, and statistical analysis
• Excellent written and oral communication skills with publication and presentation record
• May require the ability to obtain a Q clearance, which requires U.S. citizenship

Responsibilities

• Design, synthesize, purify, and characterize small molecules, peptides, chelators, molecular probes, and related bio‑molecular systems
• Develop methods to immobilize proteins, peptides, and polymers, and evaluate immobilization efficiency, stability, and retained function
• Develop quantitative assays for molecular recognition, metal binding, selectivity, kinetics, and performance in model solutions and complex matrices
• Integrate experimental results with statistical or computational analyses to guide subsequent experiments and project decisions
• Communicate results through reports, presentations, and peer‑reviewed publications

Skills

Chemical biology

Bioconjugation

Molecular design

Data analysis

Scientific writing

Education

Ph.D. in chemistry/chemical biology/biochemistry

Tools

LC-MS

NMR

HPLC

MALDI-TOF

SPPS

Job description

Los Alamos National Laboratory in Los Alamos, NM seeks a Ph.D.-level scientist in chemistry/chemical biology to contribute to a multifaceted B-TEK research program focused on bioorganic synthesis and biomolecule modification.

You will design and synthesize bio‑molecular systems, develop immobilization strategies, and create quantitative assays while collaborating across LANL and with external partners.