Postdoc: AI/ML Mammalian Bioprocess Modeling

Eli Lilly and Company; Indianapolis (IN); On-site; USD 74,000 - 101,000; Full time

Job summary

Lilly is seeking a Postdoctoral Fellow to develop and optimize mammalian cell culture processes using mechanistic and data-driven modeling approaches. You will build genome-scale and hybrid metabolic models to guide feeding strategies and medium design for early to late-stage trials.

The role emphasizes model-guided experiment design, real-time monitoring integration, and machine learning to inform decisions, with a collaborative, cross-functional team environment.

Qualifications

• PhD in Chemical/Biochemical Engineering, Bioengineering, Systems Biology, Computational Biology, Metabolic Engineering, or related field.
• Experience with constraint-based or genome-scale metabolic modeling.
• Hands-on experience in cell culture experiments (Batch, Fed-batch, Intensified Processing).

Responsibilities

• Develop and calibrate mechanistic and hybrid metabolic models of mammalian cell culture processes.
• Build computational pipelines turning bioprocess data into model inputs and predicted fluxes.
• Apply machine learning to predict performance and integrate model features with data.
• Evaluate feeding strategies and media to enhance productivity.
• Design and execute cell culture experiments from shake flasks to bench-scale bioreactors.

Skills

Constraint-based modeling

Genome-scale modeling

Python

MATLAB

Machine learning

Education

PhD in Chemical/Biochemical Engineering or related field

Tools

HPLC

UPLC

Mass spectrometry

Job description

Lilly is seeking a Postdoctoral Fellow to develop and optimize mammalian cell culture processes using mechanistic and data-driven modeling approaches. You will build genome-scale and hybrid metabolic models to guide feeding strategies and medium design for early to late-stage trials.

The role emphasizes model-guided experiment design, real-time monitoring integration, and machine learning to inform decisions, with a collaborative, cross-functional team environment.