Postdoc: AI/ML Lead for Pediatric Cancer Targets

Thecentermemphis; Memphis (TN); On-site; USD 65,000 - 85,000; Full time

Benefits offered by this job

Relocation assistance

On-site in Memphis

Job summary

The Geeleher Lab at St. Jude Children's Research Hospital in Memphis, TN, seeks a dry-lab postdoctoral scientist to lead computational and AI/ML efforts on atlas-scale pediatric single-cell and spatial datasets, aiming to nominate cell-surface antigens for dual-targeted therapies and logic-gated strategies.

You will develop AI/agent-based workflows, collaborate with wet-lab scientists, generate publication-ready analyses, and help guide study design and manuscript preparation; relocation

Qualifications

• Ph.D. in computational biology, genetics/genomics, bioinformatics, computer science, mathematics, physics, or related field.
• Strong quantitative and writing skills.
• Experience leading independent research projects.
• Publication record in peer‑reviewed journals preferred.
• Proficiency in Python or R for data analysis.

Responsibilities

• Lead independent computational/AI research projects focused on identifying and prioritizing candidate targets for emerging bispecific therapeutic strategies in pediatric cancers.
• Develop AI and agent-based workflows integrating large-scale single-cell, spatial transcriptomic, bulk genomic, functional-genomic, and pharmacologic datasets to nominate disease-selective vulnerabilities and target combinations.
• Nominate disease-selective cell-surface antigens and antigen combinations based on malignant-cell specificity, co-expression, spatial localization, normal-tissue expression, targetability, and therapeutic rationale.
• Work closely with wet-lab scientists to design follow-up validation studies and interpret experimental results in the context of large-scale datasets.
• Generate publication-quality analyses, figures, and visualizations, and contribute to study design, data interpretation, and project strategy.
• Lead projects toward publication, including drafting manuscripts, preparing methods and results sections, and responding to reviewer comments.
• Present research findings at lab meetings, institutional seminars, collaborative meetings, and scientific conferences.
• Mentor junior lab members and contribute to a collaborative wet-dry lab environment.

Skills

Strong background in quantitative/biol

Python or R

English communication

Single-cell/spatial transcriptomics

Project leadership

Education

Ph.D. in Computational Biology, Genetics/Genomics, Bioinformatics, CS, Math, Physics, or related

Job description

The Geeleher Lab at St. Jude Children's Research Hospital in Memphis, TN, seeks a dry-lab postdoctoral scientist to lead computational and AI/ML efforts on atlas-scale pediatric single-cell and spatial datasets, aiming to nominate cell-surface antigens for dual-targeted therapies and logic-gated strategies.

You will develop AI/agent-based workflows, collaborate with wet-lab scientists, generate publication-ready analyses, and help guide study design and manuscript preparation; relocation