Postdoc: AI-Driven Cardiovascular Genomics & Multi-Omics

aa067; Duarte (CA); On-site; USD 70,000 - 95,000; Full time

Job summary

City of Hope in Duarte, CA seeks a Postdoctoral Fellow in Computational Biology/Bioinformatics to join an NIH‑funded program decoding cardiomyocyte subtype dynamics and heart failure mechanisms. You will lead computational analyses, build ML/AI workflows, and integrate multi‑omics data to generate testable hypotheses and publish high‑impact research.

The role offers opportunities to develop new analytical approaches, collaborate with multidisciplinary teams, and contribute to manuscripts and

Qualifications

• PhD or MD in bioinformatics, computational biology, genomics, CS, biostatistics, biomedical sciences, or related field.
• Strong experience in bioinformatics and analysis of high‑dimensional genomic datasets.
• Strong programming skills in Python and/or R, and experience with Linux/HPC computing environments.
• Experience with single‑cell RNA‑seq, single‑nucleus RNA‑seq, sc/snATAC‑seq, or multiome analysis.
• Strong analytical, problem‑solving, scientific writing, and communication skills.

Responsibilities

• Lead computational analysis of single‑cell/single‑nucleus RNA‑seq, ATAC‑seq, and multiome datasets related to heart failure and cardiovascular biology.
• Develop and apply machine‑learning and deep‑learning approaches to identify disease‑associated cardiomyocyte subtypes, cellular trajectories, and molecular drivers.
• Develop AI agents and LLM‑based computational workflows for biomedical research, including automated dataset discovery, quality assessment, multi‑omics analysis, biological interpretation, and hypothesis generation.
• Integrate transcriptomic, epigenomic, spatial transcriptomic, and other multi‑omics datasets.
• Perform gene regulatory network, transcription factor, pathway, and cell‑state analyses.
• Develop reproducible bioinformatics pipelines and computational tools using Python and/or R.
• Work closely with Dr. Ren and experimental and computational collaborators to translate computational discoveries into experimentally testable hypotheses.
• Contribute to manuscripts, conference presentations, grant‑related research, and development of new research directions.

Skills

Bioinformatics analysis

Genomics data analysis

Python

R

Linux/HPC

Scientific writing

Communication

Education

PhD or MD in Bioinformatics/Computational Biology

Tools

Python

R

Linux

HPC

Job description

City of Hope in Duarte, CA seeks a Postdoctoral Fellow in Computational Biology/Bioinformatics to join an NIH‑funded program decoding cardiomyocyte subtype dynamics and heart failure mechanisms. You will lead computational analyses, build ML/AI workflows, and integrate multi‑omics data to generate testable hypotheses and publish high‑impact research.

The role offers opportunities to develop new analytical approaches, collaborate with multidisciplinary teams, and contribute to manuscripts and