Post Doctoral Research Associate - Fissore Lab

The University of Massachusetts Amherst; Amherst (MA); On-site; USD 63,000 - 71,000; Full time

Job summary

The University of Massachusetts Amherst is recruiting a Postdoctoral Research Associate to study signaling mechanisms underlying mammalian fertilization, focusing on calcium store refilling channels and egg activation.

You will design and perform patch-clamp, live-cell calcium imaging, and advanced imaging experiments, plus molecular analyses and collaboration with the lab team. Mentorship and manuscript preparation are part of the role.

Qualifications

• PhD in Cell Biology, Developmental/Reproductive Biology, Neurobiology, or related fields.
• Strong background in cellular and molecular biology techniques.
• Experience with live-cell imaging and calcium imaging methodologies.
• Demonstrated expertise in at least one of the following: patch-clamp electrophysiology, confocal microscopy, or fluorescence microscopy.
• Excellent written and oral communication skills.
• Ability to work independently while contributing effectively to a collaborative team environment.
• Commitment to rigorous, reproducible science and attention to detail.

Responsibilities

• Design and execute experiments using patch-clamp electrophysiology, live-cell calcium imaging, and confocal microscopy.
• Perform molecular and biochemical analyses including immunofluorescence, western blotting, and gene expression studies.
• Utilize advanced imaging techniques to visualize calcium dynamics in gametes and early embryos.
• Contribute to manuscript preparation and present findings at scientific conferences.
• Collaborate with team members and contribute to laboratory meetings and journal clubs.
• Mentor junior researchers and contribute to the training environment.
• Maintain detailed laboratory records and ensure compliance with safety and ethical protocols.

Skills

Live-cell imaging

Calcium imaging

Patch-clamp electrophysiology

Confocal microscopy

Fluorescence microscopy

Communication skills

Education

PhD in Cell Biology

Tools

Immunofluorescence

Western blotting

Gene expression analysis

Job description

Title: Post Doctoral Research Associate - Fissore Lab

Executive Area: Academic Affairs

College/School/MBU: College of Natural Sciences

Department: Veterinary & Animal Sciences

Work Location: Amherst

Schedule:Full Time

Work Arrangement:Onsite

Job Summary

The laboratory of Dr. Rafael Fissore in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst is seeking a Postdoctoral Research Associate to join our laboratory to investigate the signaling mechanisms underlying mammalian fertilization, with a particular focus on the ionic channels responsible for calcium store refilling and their role in egg activation. The functions of other divalent cations are within our research scope as well. This position offers an excellent opportunity to contribute to fundamental discoveries in reproductive biology and cellular signaling.

Essential Functions

• Design and execute cutting-edge experiments using patch-clamp electrophysiology, live-cell calcium imaging, and confocal microscopy.
• Perform molecular and biochemical analyses including immunofluorescence, western blotting, and gene expression studies.
• Utilize advanced imaging techniques to visualize and quantify calcium dynamics in gametes and early embryos.
• Contribute to manuscript preparation and presentation of findings at scientific conferences.
• Collaborate with team members and contribute to laboratory meetings and journal clubs.
• Mentor junior researchers and contribute to the training environment.
• Maintain detailed laboratory records and ensure compliance with all safety and ethical protocols.

Other Functions

• Work collaboratively and effectively to promote teamwork, equality and inclusiveness.
• Work in partnership with colleagues within the CNS community and across the campus to support the Dean's strategic priorities.
• Perform other duties as assigned in support of the mission and goals of the College of Natural Sciences.

Minimum Qualifications

• PhD in Cell Biology, Developmental/Reproductive Biology, Neurobiology, or related fields.
• Strong background in cellular and molecular biology techniques.
• Experience with live-cell imaging and calcium imaging methodologies.
• Demonstrated expertise in at least one of the following: patch-clamp electrophysiology, confocal microscopy, or fluorescence microcopy.
• Excellent written and oral communication skills.
• Ability to work independently while contributing effectively to a collaborative team environment.
• Commitment to rigorous, reproducible science and attention to detail.

Preferred Qualifications

• Previous experience studying fertilization, oocyte biology, or reproductive physiology preferred but not essential.
• Expertise in electrophysiology, particularly whole-cell recordings from oocytes or any cell type.
• Familiarity with ionic signaling.
• Experience with genetically modified model organisms (particularly mice).
• Proficiency in image analysis software.
• Experience with functional genomics approaches or gene knockdown techniques.
• Publications demonstrating a strong research track record.

Additional Details

• The Fissore lab is housed in the Integrated Science Building (ISB) on the flagship University of Massachusetts campus in Amherst. The lab is part of a highly collaborative environment that includes other department members with expertise in developmental and reproductive biology, as well as the wider community of researchers in the Cellular and Molecular Biology program, with expertise in all aspects of the biological sciences, animal models, and organ systems.
• Access to state-of-the-art equipment, including electrophysiology rigs, Ca2+ imaging and microinjection setups, and core facilities with a variety of imaging modalities and specialized imaging platforms.
• Mentorship from an experienced research team with strong publication and funding records.
• A collaborative research environment with access to interdisciplinary resources.
• Professional development opportunities including grant writing workshops and presentation training.
• Support for conference travel and continuing education.
• Potential for independent research projects and co-authorship opportunities.
• Pathway to career development in academic or industry research.

This position is subject to final budgetary and administrative approval.

Working Conditions

Work is performed in a laboratory or healthcare setting and may involve exposure to chemicals or infectious diseases. Requires standing for extended periods of time and/or use of protective gear.

Work Schedule and Work Arrangement

• Initial Appointment: 1/1/2027 - 1/1/2028 @ 100% FTE
• Monday - Friday, 8:30 am - 5:00 pm. Occasionally hours may change depending on needs of the lab and the timing of experiments.

Salary Information

• Salary minimum is determined by collective bargaining agreement based on years of experience. Salary may exceed the floor and will be determined by the PI.
• Current floors based on 100% time, 40 hours/week: 0-2 years $62,838
• 3-4 years $66,287
• 5+ years $71,033

This position will remain open for the time period required by any applicable collective bargaining agreement and will continue until a suitable candidate pool is identified. Interested applicants are strongly encouraged to apply early.