Post-Doc Research Associate - Brouwer Lab

The University of North Carolina at Chapel Hill; Chapel Hill (NC); On-site; USD 53,760 - 55,000; Full time

Job summary

The University of North Carolina at Chapel Hill is seeking a Post-Doc Research Associate for immediate appointment in the Brouwer Lab. The position involves investigating in vitro models to predict hepatic drug disposition, analyzing transport functions, and engaging in NIH-funded research on xenobiotics.

Candidates should have a Ph.D. and experience with cell culture, advanced molecular biology techniques and excellent communication skills. The work environment values collaboration and innovation, ideal for those looking to advance their research career in a supportive atmosphere.

Qualifications

• Ph.D. required with focus on relevant disciplines.
• Experience with cell culture and advanced molecular biology techniques.
• Strong communication skills and teamwork ability are essential.

Responsibilities

• Investigate in vitro models to predict hepatic drug disposition.
• Conduct transport assays and maintain laboratory safety records.
• Engage in NIH-funded research on xenobiotics and model systems.

Skills

Cell culture

Advanced molecular biology techniques

Excellent communication skills

Team collaboration

Education

Ph.D. in cell/molecular biology, biochemistry, pharmacology, pharmaceutics, engineering or related discipline

Job description

Posting Information

Posting Details

Department: SOP-DPET - 452200

Posting Open Date: 04/22/2022

Application Deadline: Open Until Filled Yes

Position Type: Postdoctoral Scholar

Position Title: Post-Doc Research Associate - Brouwer Lab

Vacancy ID: PDS003449

Full-time/Part-time: Full-Time Temporary

Hours per week: 40

FTE: 1

Work Location: Chapel Hill, NC

Position Location: North Carolina, US

Hiring Range: $53,760 - $55,000

Estimated Duration of Appointment: 12 Months

Be a Tar Heel!

The UNC Eshelman School of Pharmacy (www.pharmacy.unc.edu) is one of five health science schools (Pharmacy, Nursing, Dentistry, Public Health, Medicine) at the University of North Carolina at Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students and 145 graduate students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting‑edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School’s Strategic Plan (https://pharmacy.unc.edu/about/oe/strategic-plan/).

Primary Purpose Of Organizational Unit

Our Vision is to be the global leader in pharmacy and pharmaceutical sciences. Our Mission is to prepare leaders and innovators to solve the world’s most pressing health care challenges. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.

Position Summary

A postdoctoral research position is available immediately to investigate the utility of in vitro models (e.g., hepatic organoid 3D cell models, sandwich‑cultured hepatocytes, HuH‑7 cells, membrane vesicle systems) to (1) predict the hepatic disposition of drugs and metabolites in vivo, (2) predict the impact of disease‑mediated alterations in transport function on hepatocellular accumulation and routes of excretion (canalicular vs. basolateral) of anionic drugs/metabolites, and (3) examine hepatic transporter trafficking and regulatory mechanisms. NIH‑funded research program to study the hepatic disposition of xenobiotics utilizing in vitro model systems, regulation/trafficking of transport proteins, and cellular/molecular mechanisms responsible for hepatic structure and function. Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC‑MS/MS, maintaining the laboratory’s animal care and use and radiation safety records in accordance with institutional, state, and federal guidelines.

Minimum Education And Experience Requirements

Ph.D. in cell/molecular biology, biochemistry, pharmacology, pharmaceutics, engineering or related discipline.

Required Qualifications, Competencies, And Experience

Experience with cell culture and advanced molecular biology/biochemistry techniques. Excellent communication skills and ability to work independently as well as a member of an interdisciplinary team are essential.

Preferred Qualifications, Competencies, And Experience

Preference will be given to candidates with expertise in pharmacokinetic modeling and simulation, and drug‑induced liver injury.

Special Physical/Mental Requirements

Position will require some night and weekend bench and manuscript work. Position includes exposure to lab animals, human hepatocytes, adenoviral vector, and radiolabeled BSL‑2 compounds.

Special Instructions

For information on UNC Postdoctoral Benefits and Services click here

Posting Contact Information

Department Contact Name and Title: Kim L. R. Brouwer, PharmD, PhD, Distinguished Professor

Department Contact Telephone or Email: [e-mail]

Postdoctoral Affairs Contact Information: If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at [phone] or send an email to [e-mail]. Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

Equal Opportunity Employer Statement

The University is an equal opportunity, employer and welcomes all to apply without regard to age, color, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, or sexual orientation. We encourage all qualified applicants to apply, including protected veterans and individuals with disabilities.