Post-Doc Research Associate - Brouwer Lab

PeopleAdmin, Inc.; Chapel Hill (NC); On-site; USD 53,760 - 55,000; Full time

Job summary

A leading research university in North Carolina is seeking a postdoctoral researcher to investigate in vitro models for predicting drug disposition and regulatory mechanisms in liver functions. The successful candidate must hold a Ph.D. in a relevant discipline and possess strong skills in cell culture and molecular biology techniques. This NIH-funded position emphasizes teamwork and communication in a dynamic research environment. Potential for long-term impact in pharmacy and health sciences.

Qualifications

• Ph.D. in relevant discipline.
• Experience with advanced molecular biology techniques.
• Excellent communication and teamwork abilities.

Responsibilities

• Conduct in vitro culture experiments.
• Perform transport assays and Western Blotting.
• Maintain laboratory health and safety records.

Skills

Cell culture

Molecular biology techniques

Communication skills

Interdisciplinary teamwork

Education

Ph.D. in cell/molecular biology, biochemistry, pharmacology, or related discipline

Job description

For information on UNC Postdoctoral Benefits and Services click here

Posting Information

Department

Posting Open Date 04/22/2022

Application Deadline Open Until Filled Yes

Position Type Full-Time Temporary

Position Title

Vacancy ID PDS003449

Full-time/Part-time Full-Time Temporary

Hours per week 40

FTE 1

Work Location North Carolina, US

Hiring Range $53,760 - $55,000

Estimated Duration of Appointment 12 Months

Position Information

The UNC Eshelman School of Pharmacy is one of five health science schools at UNC Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students and 145 graduate students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting‑edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School’s Strategic Plan.

Our Vision is to be the global leader in pharmacy and pharmaceutical sciences. Our Mission is to prepare leaders and innovators to solve the world’s most pressing health care challenges. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.

Position Summary

A postdoctoral research position is available immediately to investigate the utility of in vitro models (e.g., hepatic organoid 3D cell models, sandwich-cultured hepatocytes, HuH‑7 cells, membrane vesicle systems) to (1) predict the hepatic disposition of drugs and metabolites in vivo, (2) predict the impact of disease‑mediated alterations in transport function on hepatocellular accumulation and routes of excretion (canalicular vs. basolateral) of anionic drugs/metabolites, and (3) examine hepatic transporter trafficking and regulatory mechanisms.

This is an NIH‑funded research program to study the hepatic disposition of xenobiotics using in vitro model systems, regulation/trafficking of transport proteins, and cellular/molecular mechanisms responsible for hepatic structure and function. Research includes but is not limited to: in vitro cell culture experiments, transport assays, Western Blotting, cloning and mutagenesis, immunohistochemical imaging and live cell imaging, LC‑MS/MS, maintaining the laboratory’s animal care and use and radiation safety records in accordance with institutional, state, and federal guidelines.

Minimum Education and Experience Requirements

Ph.D. in cell/molecular biology, biochemistry, pharmacology, pharmaceutics, engineering or related discipline.

Required Qualifications, Competencies, and Experience

Experience with cell culture and advanced molecular biology/biochemistry techniques. Excellent communication skills and ability to work independently as well as a member of an interdisciplinary team are essential.

Preferred Qualifications, Competencies, and Experience

Preference will be given to candidates with expertise in pharmacokinetic modeling and simulation, and drug‑induced liver injury.

Special Physical/Mental Requirements

Position will require some night and weekend bench and manuscript work. Position includes exposure to lab animals, human hepatocytes, adenoviral vector, and radiolabeled BSL‑2 compounds.

Department Contact Telephone or Email

If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at [phone] or send an email to [e-mail]. Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

Equal Opportunity Employer Statement

The University is an equal opportunity, employer and welcomes all to apply without regard to age, color, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, or sexual orientation. We encourage all qualified applicants to apply, including protected veterans and individuals with disabilities.

Optional and Required Documents

Required Documents

• Curriculum Vitae / Resume
• Cover Letter
• List of References
• Research Statement

Optional Documents

• Degree Transcripts
• Writing/research Sample

Supplemental Questions

Required fields are indicated with an asterisk (*).

• * The School’s vision is grounded in our aspiration to be a diverse and inclusive community of people who accelerate new thinking and ideas in education, research, and practice that have a positive impact on human health worldwide. We envision a school that reflects, in all its dimensions, the population it serves. Using the field below, please provide a diversity statement that outlines examples of your commitment to diversity, equity, inclusion, and belonging, as well as how you will contribute to an inclusive environment at the UNC Eshelman School of Pharmacy. (Note: There is no word count/character limit.)