Post Doc, R&D Immunology - Population Analytics & Insights

Biopharma Asia; Pennsylvania; On-site; USD 79,000 - 128,000; Full time

Benefits offered by this job

Vacation 120h

Sick leave 40h

Holiday pay

Parental Leave

Job summary

Johnson & Johnson Innovative Medicine (JJIM) is recruiting a Postdoctoral Scholar to work in the Data Sciences organization on drug target identification and evaluation to support alignment with Immunology priorities. The primary location is Spring House, PA.

The Data Science Analytics & Insights group develops innovative solutions using diverse data sources to advance the drug discovery pipeline. You will analyze large-scale clinical, genetic, omics, and phenotypic data to support target

Qualifications

• PhD in a quantitative field with strong biological basis (bioinformatics, computational biology, systems biology, statistical genetics, or related).
• Completed PhD program.
• Experience with multi-omic data (RNA expression, proteomics, epigenomics, genetics) at bulk and single-cell levels.
• Working knowledge of databases and analysis approaches for gene/pathway ontology, such as network analysis.
• Proficient in programming and computational skills and ability to collaborate with scientists to meet timelines.
• Independent, self-motivated, innovative, and able to excel in a fast-moving team.
• Strong communication, organizational and leadership skills; publication track record.

Responsibilities

• Construct analytic framework integrating perturbation, ontology and cellular phenotyping with omics data.
• Apply inference and ML methods to link targets to disease pathways and assess off-target toxicity.
• Model multimodal data to predict pathway activity and synergy.
• Analyze phenomic and multiomic data to identify targets and biomarkers.
• Provide design and analysis consultation to Immunology colleagues.
• Translate computational findings to support biological validation.

Skills

NLP/ML/AI experience

Leadership

Python

R

Network analysis

Education

PhD in quantitative field

Tools

Python

R

Network analysis

NLP

ML/AI

LLM

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Career Programs

Job Sub Function:

Post Doc – R&D Product Development

Job Category:

Career Program

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson and Johnson Innovative Medicine (JJIM) is recruiting a Postdoctoral Scholar to work within the group (Data Sciences organization) on drug target identification and evaluation to support alignment of priorities with the Immunology therapeutic area.

The primary location for this position is Spring House, PA

The Data Science Analytics & Insights organization develops innovative solutions using a variety of data sources across multiple different disease areas. We are looking for a highly motivated and self-driven individual who will creatively analyze large-scale clinical, genetic, omics and cell phenotype data to advance our drug discovery pipeline in R&D.

At J&J, we strive to bring in the brightest minds in pursuit of developing effective and safe therapeutics for patients around the globe.

Role & responsibilities:

Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.

Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions. These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.

Provide scientific technical expertise in modeling multimodal data (including genetic, transcriptomics, proteomic and functional data) to predict target pathway activity and synergistic effects.

Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.

Provide design and analysis consultation for questions of interest to our Immunology colleagues and facilitate interactions between colleagues across the organization.

Translate findings from computational analyses to support functional, biological and pharmacological validation.

Job Qualifications:

Required skills

A Ph.D. in a quantitative field with a strong biological basis – Bioinformatics, Computational Biology, Systems Biology, Statistical Genetics, or related fields.

Completed PhD program.

Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level.

Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis.

Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines.

Independent, self-motivated, innovative, and able to excel in a goal-oriented, multifaceted and fast-moving team environment.

Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams.

Preferred skills

Experience working with Immunology projects.

Expertise in perturbation data and analysis.

Experience with advanced analytical approaches (NLP, ML/AI, LLM) to extracting relevant sources of annotation of cellular states, functions and localization from unstructured data.

Experience with predictive models associated with evaluation of target engagement and druggability.

Experience with drug discovery and development practices and project support in a large pharmaceutical setting.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected under federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource.

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is :

$79,000.00 - $127,650.00

Additional Description for Pay Transparency:

ubject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

Benefits:

• Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period10 days
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits