Post Doc (0)

International Cell Senescence Association; Post (OR); On-site; USD 52,000 - 68,000; Full time

Job summary

University of Massachusetts Chan Medical School (UMCMS) in Worcester, MA, seeks a Postdoctoral Researcher to identify senescent cell types and immune niches that promote tumor progression using cutting-edge single-cell and spatial transcriptomics.

The role focuses on the impact of age-related senescence on prostate cancer onset and immune suppression, aiming to translate findings into therapeutic strategies for deadly cancers.

Qualifications

• PhD and/or MD in Biology or related field with no more than 1 year of postdoctoral experience.
• First author publication from PhD/MD research in a peer-reviewed journal.
• At least 1 year of mouse experience.
• Background in cancer biology.
• Technical proficiency in cell culture and molecular biology.

Responsibilities

• Identify heterogeneous senescent cell types and immune cell niches using single-cell and spatial transcriptomic approaches.
• Determine the impact of age-related senescence on prostate cancer onset and immune suppression.
• Contribute to translating basic senescence biology into therapeutic strategies for cancer.

Skills

First author publication

Mouse experience

Background in cancer biology

Cell culture techniques

Molecular biology techniques

Strong self-motivation

Collaboration

Deadline-driven

Independent experimentation

Genome editing experience

Education

PhD and/or MD in Biology or related field

Tools

Genome editing technologies

Histology

Microscopy

Immunology

Flow cytometry

High-throughput sequencing

Job description

Identifying mechanisms and therapeutic targets of stromal senescence in prostate cancer development

A Postdoctoral Research Position Supported By Long-term NIH R37 Grant Funding Is Available In The Laboratory Of Marcus Ruscetti, Ph.D. To Work On Projects To

• Uncover heterogeneous senescent cell types and immune cell niches that promote tumor progression using single cell and spatial transcriptomic approaches.
• Determine the impact of age-related senescence on prostate cancer onset and immune suppression.

These projects, and my laboratory, lie at the intersection of cancer genetics and tumor immunology, and at the interface of basic science and translational medicine. Our long-term goals will be to translate our basic understanding of how senescence biology regulates critical tumor-immune interactions into the development of therapeutic strategies to treat patients with deadly pancreatic and prostate cancers.

Our lab is part of the Department of Molecular, Cell and Cancer Biology (MCCB) at the University of Massachusetts Chan Medical School (UMCMS) in Worcester, MA, giving us access to a multitude of state-of-the-art core facilities, shared equipment, and a highly stimulating and interactive intellectual environment. UMCMS is a vibrant and exciting research community, with ~3,000 faculty, including ~320 basic science principal investigators and ~2,500 clinical faculty. The UMCMS faculty includes members of the National Academy of Sciences, the Howard Hughes Medical Institute, and the American Academy of Arts and Sciences. UMCMS faculty have won several major awards, including the Keck Award, the Lasker Prize, and the Nobel Prize in Physiology or Medicine, among others.

Qualifications

• A recent Ph.D. and/or M.D. degree in Biology, or a related field, with no more than 1 year of postdoctoral experience
• A 1st author publication in a peer-reviewed scholarly journal from their Ph.D. and/or M.D. research
• Previous mouse experience (at least 1 year)
• A prior background in cancer biology
• Technical proficiency in cell culture and molecular biology techniques.

Candidates With The Following Qualifications Are Encouraged To Apply

• Strong self-motivation
• Ability to collaborate within and outside the laboratory
• Ability to plan, organize and meet deadlines
• Ability to independently develop, execute, and analyze experiments
• Experience in genome-editing technologies, histology, microscopy, immunology, flow cytometry, and high-throughput sequencing.