Pilot Plant Downstream Processing Operator

Manus; Augusta (GA); On-site; USD 52,000 - 78,000; Full time

Job summary

Manus seeks a self-motivated laboratory operations specialist for its Augusta BioFacility. The role involves supporting fermentation and downstream processing, operating purification equipment, and ensuring safe, compliant pilot plant activities.

The candidate should bring at least 3 years in related plant operations and a strong teamwork mindset. The position requires physical work including lifting up to 50 pounds, exposure to hazardous materials with proper PPE, and shift work alignment with

Qualifications

• Requires a high school diploma or GED.
• Minimum 3 years downstream or related plant operator experience.
• Ability to follow minimal instructions and support safe work practices.
• Strong teamwork and communication skills; collaborative mindset.
• Flexible with day-to-day duties; adapt to startup environment.
• Familiarity with fermentation/downstream processes and equipment.
• Basic PC skills; Windows and MS Office.

Responsibilities

• Interface with process development to support fermentation and product isolation tasks.
• Execute downstream purification operations including centrifugation, chromatography, filtration.
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in‑process and final product samples.
• Monitor process parameters and maintain batch documentation.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure product quality.
• Maintain DSP consumables inventory and request resupply as needed.
• Adhere to safety and environmental policies; maintain PPE as required.

Skills

Teamwork

Communication

Safety minded

Flexibility

Process knowledge

Education

High school diploma or GED

Tools

SAP

DeltaV controls

Job description

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a self‑motivated and highly organized individual for a position that will specialize in laboratory operations at our Augusta BioFacility.

Why Work At Manus

• Opportunity – For motivated, results‑oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Responsibilities

• Interface with process development team to provide resources to solve fermentation and product isolation challenges. Execute and help evaluate experiments. This activity includes:
• Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in‑process and final product samples.
• Monitor process parameters, record data, and ensure batch documentation is completed accurately.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
• Maintain inventory of DSP consumables and request resupply as needed.
• Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
• Execute day‑to‑day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; be capable of correcting minor maintenance issues.
• Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
• Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.

Working Hazards And Conditions

• This position involves work on the third floor of the facility and requires occasional manual handling of hazardous materials, including carrying pitchers of sulfuric acid and glassware (such as beakers, flasks, and similar lab equipment).
• The role also involves working around hot steam tanks, requiring strict adherence to safety procedures and use of appropriate personal protective equipment (PPE) at all times.
• At certain times, the employee may be required to work alone, necessitating compliance with Manus Bio’s lone worker safety protocols to ensure proper communication and emergency preparedness.
• Employees must maintain a heightened awareness of their surroundings, follow all established chemical handling and steam safety procedures, and participate in mandatory hazard and emergency response training.
• Must be able to wear the required protective equipment, including respirators when needed.
• Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Required Qualifications

• High school diploma or GED equivalent.
• Minimum of 3 years downstream or related plant operator experience.
• Must be able to follow minimal instructions and support safe work practices.
• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must be flexible with day‑to‑day duties and able to thrive in a start‑up environment.
• Must hold themselves to the highest professional and ethical standards.
• Some familiarity with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
• Demonstrates flexibility in job rotations/various assignments.
• Basic PC skills which include Windows, Microsoft Office.

Preferred Qualifications And Working Style

• SAP skills
• Certified Train the Trainer skills
• Delta V controls experience