Pilot Plant Fermentation Operator

Manus; Augusta (GA); On-site; USD 60,000 - 85,000; Full time

Benefits offered by this job

None

Job summary

Manus Bio in Augusta, GA is seeking a Pilot Plant Fermentation Operator to support manufacturing and process development. You will work with the process development team to run fermentation operations, collect data, and help optimize downstream purification steps.

The role requires a high school diploma, at least 3 years of downstream or related plant operator experience, and a collaborative mindset. You will operate equipment, maintain cleanroom standards, and contribute to safe, compliant

Qualifications

• High school diploma or GED required.
• Strong teamwork and collaboration skills.
• Willingness to work in startup environment.
• Basic PC skills including Windows & MS Office.
• Must follow safety and cleanroom practices.

Responsibilities

• Interface with process development team to provide resources to solve fermentation and product isolation challenges.
• Execute and help evaluate experiments.
• Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in‑process and final product samples.
• Monitor process parameters, record data, and ensure batch documentation is completed accurately.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
• Maintain inventory of DSP consumables and request resupply as needed.
• Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
• Execute day‑to‑day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; be capable of correcting minor maintenance issues.
• Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
• Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.
• Must be able to wear the required protective equipment, including respirators when needed.
• Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Skills

Team communication

Attention to detail

Problem solving

Team player

Flexibility

Education

High school diploma or GED

Tools

SAP

DeltaV controls

Microsoft Office

Job description

Pilot Plant Fermentation Operator, Augusta, Georgia, United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a highly motivated Pilot Plant Fermentation Operator. This person will be expected to play an integral part of Manus Bio’s manufacturing and process development team located in Augusta, GA.

Why Work At Manus Bio

• Opportunity – For motivated, results‑oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that come with working on the cutting edge.

Responsibilities

Interface with process development team to provide resources to solve fermentation and product isolation challenges. Execute and help evaluate experiments. This activity includes:

• Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in‑process and final product samples.
• Monitor process parameters, record data, and ensure batch documentation is completed accurately.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
• Maintain inventory of DSP consumables and request resupply as needed.
• Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
• Execute day‑to‑day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; be capable of correcting minor maintenance issues.
• Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
• Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.
• Must be able to wear the required protective equipment, including respirators when needed.
• Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Required Qualifications

• High school diploma or GED equivalent.
• Minimum of 3 years downstream or related plant operator experience.
• Must be able to follow minimal instructions and support safe work practices.
• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must be flexible with day‑to‑day duties and able to thrive in a start‑up environment.
• Must hold themselves to the highest professional and ethical standards.
• Some familiarity with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
• Demonstrates flexibility in job rotations/various assignments.
• Basic PC skills which include Windows, Microsoft Office.

Preferred Qualification And Working Style

• SAP skills
• Certified Train the Trainer skills
• Delta V controls experience