NPI Scientist — Scale-Up & Tech Transfer

Nautilus Bio; San Carlos (AZ); On-site; USD 120,000 - 170,000; Full time

Job summary

Nautilus Bio is seeking a Scientist or Senior NPI Scientist to bridge R&D and manufacturing, focusing on developing and refining methods for production and testing of our processes and products. You will transfer reagents, proteins, antibodies, and sequencing assays from research to commercialization.

You will design scale-up studies, improve yield and stability, author essential documents, and collaborate with R&D to define QC criteria.

Qualifications

• PhD in chemistry, biochemistry, molecular biology or a related field with 2–3 years of industry experience; or an MS with 3–5 years, or a BS with 5–7+ years of relevant industry experience.
• Deep knowledge of protein biochemistry, protein purification, reagent formulation or analytical chemistry (HPLC, MS, FPLC).
• Experience in BOM setup using Arena/Agile software, costing analysis, supply chain setup, vendor management.
• Hands-on experience in controlled development or manufacturing environment (ISO9001 & ISO 13485).
• Strong interpersonal and communication skills, with the ability to document processes clearly and train others to execute SOPs.
• Proficiency in Excel; familiarity with project tracking tools (Smartsheet, Microsoft Project, or similar).
• Willingness to work hands-on in lab and production environments.
• Demonstrate project management skills with ability to meet timelines and deliverables.

Responsibilities

• Own the transfer of newly developed reagents, proteins, antibodies and sequencing assays from R&D to commercial.
• Design, develop and optimize scale-up studies; improve yield, stability and robustness of formulations and processes.
• Author SOPs, batch records, and technical reports; ensure compliance with quality standards.
• Conduct root-cause analysis and provide technical support to resolve production-line anomalies during pilot and production phases.
• Partner with R&D to establish QC release criteria and specifications for manufactured reagents.
• Perform hands-on lab and production work, including reagent formulation, conjugation, and analytical sample preparation.

Skills

Project management

Documentation

Interpersonal communication

Lab hands-on

Problem solving

Education

PhD in chemistry/biochemistry/molecular biology (2–3 yrs industry)

MS with 3–5 yrs industry

BS with 5–7+ yrs industry

Tools

Arena/Agile software

Excel

Smartsheet

Microsoft Project

Job description

Nautilus Bio is seeking a Scientist or Senior NPI Scientist to bridge R&D and manufacturing, focusing on developing and refining methods for production and testing of our processes and products. You will transfer reagents, proteins, antibodies, and sequencing assays from research to commercialization.

You will design scale-up studies, improve yield and stability, author essential documents, and collaborate with R&D to define QC criteria.