Night-Shift Peptide Synthesis Scientist

Capable Labs; San Francisco (CA); On-site; USD 90,000 - 120,000; Full time

Benefits offered by this job

Equity options

Wellness budget

Healthcare coverage

HSA/FSA/401K

Daily team dinners

Job summary

Capable Labs is seeking a dedicated team member to run overnight peptide-synthesis workflows in a San Francisco laboratory. You will own the overnight execution, troubleshoot issues, and hand off clear results to the day team.

You will perform resin loading, coupling, deprotection, purification, and characterization, using HPLC/LC-MS as needed, with meticulous record-keeping and precise sample handoffs.

Qualifications

• Hands-on chemistry or biochemistry laboratory experience.
• Interest in owning the overnight synthesis workflow from reaction execution through purification, characterization, documentation, and sample handoff.
• Experience with solid-phase peptide synthesis, HPLC, prep HPLC, or LC-MS is valuable, but training can be provided.

Responsibilities

• Execute overnight peptide synthesis workflows, including resin loading, coupling and deprotection cycles, cleavage, purification, characterization, and sample preparation.
• Run microwave-assisted solid-phase peptide synthesis and support routine synthesizer maintenance during night-shift hours.
• Troubleshoot failed couplings, low crude purity, side products, cleavage issues, and instrument downtime.
• Purify and characterize candidates using analytical HPLC, prep HPLC, LC-MS, and related methods.
• Record identity, purity, yield, analytical traces, and batch-level quality-control data for morning handoff.
• Prepare compounds for in vitro and in vivo testing and maintain accurate experimental records.
• Provide clear handoffs covering completed work, failures, results, sample locations, risks, and follow-up actions.

Skills

Night shift

Laboratory experience

Peptide synthesis

Analytical techniques

Tools

HPLC

LC-MS

Job description

Capable Labs is seeking a dedicated team member to run overnight peptide-synthesis workflows in a San Francisco laboratory. You will own the overnight execution, troubleshoot issues, and hand off clear results to the day team.

You will perform resin loading, coupling, deprotection, purification, and characterization, using HPLC/LC-MS as needed, with meticulous record-keeping and precise sample handoffs.