NGS Scientist

Integrated Resources, Inc ( IRI ); Sunnyvale (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Integrated Resources, Inc (IRI) seeks an experienced Scientist to develop and optimize automated molecular biology workflows for next-generation sequencing (NGS) applications. The role emphasizes hands-on laboratory work, integrating complex workflows into cartridge-based consumables for closed-environment sample preparation and sequencing library construction.

The ideal candidate has 3-5 years in molecular biology or genomics, with hands-on NGS library preparation and automation experience,

Qualifications

• Bachelor's or master's degree in molecular biology, Genetics, Biochemistry, Biotechnology, Microbiology, or related scientific discipline.
• 3-5 years of relevant laboratory experience in molecular biology or genomics.
• Demonstrated hands-on experience with NGS library preparation workflows.
• Experience operating and troubleshooting laboratory automation platforms.
• Experience integrating molecular biology processes into automated workflows.
• Strong understanding of PCR, DNA extraction, nucleic acid quantification, and sequencing QC techniques.
• Experience with common genomics instrumentation and analytical software tools.
• Excellent experimental design, data analysis, documentation, and communication skills.
• Ability to independently plan and execute laboratory experiments with minimal supervision.

Responsibilities

• Execute and optimize automated nucleic acid extraction, amplification, and NGS library preparation workflows.
• Support the development of cartridge-based sample-to-library preparation systems for sequencing applications.
• Design, perform, analyze, and document experiments evaluating workflow performance, robustness, and reproducibility.
• Troubleshoot molecular biology processes integrated into automated fluidic and consumable platforms.
• Perform DNA/RNA quantification, library QC, normalization, pooling, and sequencing preparation.
• Collaborate with multidisciplinary teams including assay development, automation engineering, bioinformatics, consumables development, and systems engineering.
• Generate detailed experimental reports, protocols, and technical documentation.
• Analyze experimental data and communicate findings to project teams and leadership.
• Support technology transfer, verification, and validation activities as development projects mature.
• Maintain accurate laboratory records and ensure compliance with established laboratory practices and safety procedures.
• Contribute to continuous improvement of automated workflows and laboratory processes.

Skills

NGS library preparation

Laboratory automation

PCR

DNA extraction

Nucleic acid quantification

Experiment design

Data analysis

Documentation

Cross-functional collaboration

Safety compliance

Education

Bachelor's or Master's in molecular biology or related

Tools

NGS instrumentation

Job description

• We are seeking an experienced Scientist to support the development and optimization of automated molecular biology workflows for next-generation sequencing (NGS) applications.
• The candidate should have experience in laboratory automation, nucleic acid sample processing, and NGS library preparation.
• Experience in hands‑on NGS workflow is a must.
• Experience with NGS data analysis is highly preferred.
• This hands‑on laboratory role focuses on integrating complex molecular biology workflows into automated, cartridge‑based consumables designed to enable sample preparation and sequencing library construction in a closed environment.
• The ideal candidate is an engaged and self‑motivated experimentalist.

Key Responsibilities:

• Execute and optimize automated nucleic acid extraction, amplification, and NGS library preparation workflows.
• Support the development of cartridge‑based sample‑to‑library preparation systems for sequencing applications.
• Design, perform, analyze, and document experiments evaluating workflow performance, robustness, and reproducibility.
• Troubleshoot molecular biology processes integrated into automated fluidic and consumable platforms.
• Perform DNA/RNA quantification, library QC, normalization, pooling, and sequencing preparation.
• Collaborate with multidisciplinary teams including assay development, automation engineering, bioinformatics, consumables development, and systems engineering.
• Generate detailed experimental reports, protocols, and technical documentation.
• Analyze experimental data and communicate findings to project teams and leadership.
• Support technology transfer, verification, and validation activities as development projects mature.
• Maintain accurate laboratory records and ensure compliance with established laboratory practices and safety procedures.
• Contribute to continuous improvement of automated workflows and laboratory processes.

Required Qualifications

• Bachelor's or master's degree in molecular biology, Genetics, Biochemistry, Biotechnology, Microbiology, or related scientific discipline.
• 3-5 years of relevant laboratory experience in molecular biology or genomics.
• Demonstrated hands‑on experience with NGS library preparation workflows.
• Experience operating and troubleshooting laboratory automation platforms.
• Experience integrating molecular biology processes into automated or semi‑automated workflows.
• Strong understanding of PCR, DNA extraction, nucleic acid quantification, and sequencing library QC techniques.
• Experience with common genomics instrumentation and analytical software tools.
• Excellent experimental design, data analysis, documentation, and communication skills.
• Ability to independently plan and execute laboratory experiments with minimal supervision.

Preferred Qualifications

• Experience developing or optimizing workflows within cartridge‑based or consumable‑based automated systems.
• Experience working with Oxford Nanopore, Illumina, or related sequencing technologies.
• Familiarity with automated magnetic bead purification and nucleic acid cleanup workflows.
• Experience supporting regulated product development, verification, or validation activities.
• Knowledge of assay development principles and sequencing workflow optimization.
• Experience in working with biological samples
• Experience working in a cross‑functional product development environment.
• This is a laboratory‑based position requiring daily on‑site participation and hands‑on experimental work.