Neurotech: Non-Viral Gene Delivery Scientist

merge.io; California; In loco; USD 120.000 - 190.000; Tempo pieno

Descrizione del lavoro

Merge Labs seeks a Scientist to develop non-viral gene delivery approaches enabling neural activity sensors in preclinical models. You will bridge molecular engineering and in vivo function, contributing to clinical translation of molecular brain-computer interfaces.

You will collaborate with protein engineers, neurobiologists, and data scientists; lead hands-on formulations, design in vivo studies, and drive projects to results in a fast-paced, multidisciplinary setting.

Competenze

• Ph.D. or equivalent with leadership of research projects end-to-end.
• Hands-on with non-viral delivery vehicles (lipid or polymeric nanoparticles).
• Experience developing, optimizing, or evaluating gene delivery modalities.
• In vivo studies in rodents and potentially large animals; interpretation of delivery results.

Mansioni

• Identify best non-viral delivery technologies and secure access via collaborations or licenses.
• Formulate and characterize LNPs and other delivery vehicles for CNS delivery.
• Define success criteria and develop assays/readouts for efficacy and tolerability.
• Design and run in vivo studies in rodents and large animals as appropriate.
• Evaluate pairing of delivery technologies with ultrasound-assisted BBB opening.
• Assess durability of expression and consider manufacturability and cost of goods.
• Collaborate on payload design and expression requirements; mentor research staff.

Conoscenze

Non-viral delivery

Lipid nanoparticles (LNPs)

Polymeric nanoparticles

In vivo studies

Preclinical translation

Interdisciplinary collaboration

Formazione

Ph.D. or equivalent experience

Strumenti

LNP formulation

Microfluidic formulation

Analytical characterization

Descrizione del lavoro

Merge Labs seeks a Scientist to develop non-viral gene delivery approaches enabling neural activity sensors in preclinical models. You will bridge molecular engineering and in vivo function, contributing to clinical translation of molecular brain-computer interfaces.

You will collaborate with protein engineers, neurobiologists, and data scientists; lead hands-on formulations, design in vivo studies, and drive projects to results in a fast-paced, multidisciplinary setting.