Neural Gene Delivery Scientist (AAV & CNS)

merge.io; California; Presencial; USD 150.000 - 185.000; Jornada completa

Descripción de la vacante

Merge Labs in California seeks a Scientist to engineer and validate viral gene delivery approaches that enable molecular biosensors and actuators of neural activity in preclinical models. You will bridge molecular engineering and in vivo functionality to support clinical translation of molecular BCI.

You will collaborate with protein engineers, cell and synthetic biologists, ML engineers, physicists and neuroscientists across a fast-paced, cross-disciplinary team.

Formación

• Ph.D. or equivalent experience leading research projects end-to-end in bioengineering, neuroscience, virology, cell biology, molecular biology or a related field.

Responsabilidades

• Design, build, and test AAV and other viral vectors for gene delivery to the CNS, spanning serotype selection, cargo and regulatory element design, dose, and route of administration.
• Design, run, and interpret in vivo studies in rodents and, where appropriate, large animal models, iterating rapidly from results to the next round of optimization.
• Evaluate and benchmark routes of administration for viral gene delivery to the brain, including pairing of viral vectors with focused ultrasound blood-brain barrier opening.
• Build or adapt the assays and readouts needed to quantify delivery, expression, cell-type specificity, and tolerability in brain tissue.
• Evaluate emerging delivery technologies and help shape the team's longer-term delivery strategy. Make data-driven calls on which routes and technologies to advance.

Conocimientos

End-to-end research

In vivo experiments

AAV vectors design

Team collaboration

Educación

Ph.D. or equivalent

Descripción del empleo

Merge Labs in California seeks a Scientist to engineer and validate viral gene delivery approaches that enable molecular biosensors and actuators of neural activity in preclinical models. You will bridge molecular engineering and in vivo functionality to support clinical translation of molecular BCI.

You will collaborate with protein engineers, cell and synthetic biologists, ML engineers, physicists and neuroscientists across a fast-paced, cross-disciplinary team.