mRNA Process Development Scientist

American Society of Gene & Cell Therapy; Waltham (MA); On-site; USD 105,000 - 145,000; Full time

Job summary

ElevateBio is seeking an experienced mRNA Scientist to join the process development team. The role focuses on designing, executing, and optimizing mRNA production and purification while supporting tech transfer to clients and partners.

Responsibilities include development, characterization of mRNA samples, cross-functional collaboration, and creation of SOPs. A strong background in IVT, downstream processes, and scale-up to GMP is required.

Qualifications

• BS/MS in Microbiology, Bioengineering, Biochemistry, or related with 8+ years experience, including 4+ years with mRNA therapeutics.
• Hands-on experience in IVT and plasmid DNA linearization.
• Downstream mRNA methods including TFF and chromatography such as dT Affinity, IEX, RP-HPLC.
• Experience with ÄKTA Avant or similar systems and filtration skids.
• Understanding tech transfer for mRNA drug substances.
• Experience scaling processes from bench to GMP manufacturing.

Responsibilities

• Lead development, optimization, and scale-up of mRNA processes for yields and purity.
• Characterize mRNA samples using electrophoresis, spectrophotometry, and HPLC/UPLC.
• Collaborate with MSAT, analytical development, and external clients to support projects.
• Assist business development with SOWs and proposals for mRNA therapeutics partnerships.
• Communicate results and progress to stakeholders and clients.
• Contribute to SOPs and technical documentation.

Skills

mRNA processing

IVT

Chromatography

Tech transfer

GMP manufacturing

DoE

SOPs

Education

BS/MS in Microbiology/Bioengineering

Tools

ÄKTA Avant

Repligen Kr2i

HPLC/UPLC

Job description

ElevateBio is seeking an experienced mRNA Scientist to join the process development team. The role focuses on designing, executing, and optimizing mRNA production and purification while supporting tech transfer to clients and partners.

Responsibilities include development, characterization of mRNA samples, cross-functional collaboration, and creation of SOPs. A strong background in IVT, downstream processes, and scale-up to GMP is required.