mRNA Development Co-Op: Hands-On Biotech Lab Experience

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 34,000 - 48,000; Full time

Job summary

Serif Biomedicines, Inc. is seeking a motivated Co-Op to join the Chemistry, Manufacturing, and Controls team.

This position offers hands-on benchwork, rigorous scientific inquiry, and collaboration in a fast-paced, entrepreneurial setting. You will gain exposure to mRNA synthesis, purification workflows, and analytical characterization while operating with state-of-the-art lab equipment and documentation practices.

Qualifications

• Current student enrolled in a master’s or bachelor’s degree in chemical engineering, biology, biotechnology, or biochemistry.
• Familiarity with IVT and enzymatic reactions.
• Experience with HPLC/FPLC purification and instrumentation.
• Knowledge of TFF instrumentation and nucleic acid analytics.

Responsibilities

• Synthesize and purify mRNA products for preclinical studies.
• Optimize and scale up enzymatic reactions for mRNA synthesis.
• Optimize and scale up purification workflow for nucleic acids using chromatography, filtration, and enzymatic steps.
• Perform high-throughput screens to optimize IVT and automated purification instrumentation.
• Operate and maintain lab instruments including FPLC AKTA systems, TFF systems, and biosafety cabinets.
• Characterize mRNA drug substance using analytical techniques such as gel electrophoresis and endotoxin measurement.
• Maintain an electronic lab notebook and project documentation.
• Present findings at team and cross-functional meetings.

Skills

Enzymatic reactions familiarity

IVT familiarity

HPLC/FPLC purification

TFF instrumentation

Nucleic acid analytics

RNase-free handling

Time management

Communication skills

Microsoft Office

Education

Bachelor's or Master's in Chemical Engineering / Biology / Biotechnology / Biochemistry

Tools

AKTA FPLC systems

TFF systems

BSCs

UV spectroscopy

Job description

Serif Biomedicines, Inc. is seeking a motivated Co-Op to join the Chemistry, Manufacturing, and Controls team.

This position offers hands-on benchwork, rigorous scientific inquiry, and collaboration in a fast-paced, entrepreneurial setting. You will gain exposure to mRNA synthesis, purification workflows, and analytical characterization while operating with state-of-the-art lab equipment and documentation practices.