Molecular Histologist

Insight Global; Collegeville (PA); On-site; USD 59,236 - 66,124; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

401k with Employer Matching

Paid Sick Leave

Job summary

A leading pharmaceutical company is seeking a Molecular Histologist with expertise in advanced histotechniques and quantitative image analysis. The role involves performing molecular and imaging histology work across various therapeutic areas, focusing on neurodegenerative and liver diseases. The candidate will collaborate with interdisciplinary teams to support drug development through innovative histology techniques and data analysis.

Qualifications

• PhD or MS with 3 years experience in molecular imaging histology.
• Strong skills in histotechniques and data analysis.

Responsibilities

• Develop and validate assays using histotechniques.
• Execute experiments and analyze data for drug development.

Skills

Histotechniques

Data Analysis

Experimental Design

Education

PhD in Histopathology

MS in Molecular Biology

BS in Molecular Biology

Tools

HALO

Visiopharm

Ventana Discovery Ultra

Zeiss AxioScan

Job description

5 days ago Be among the first 25 applicants

This range is provided by Insight Global. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$43.00/hr - $48.00/hr

Required Skills & Experience

- PhD or equivalent in histopathology, immunology, or cellular and molecular biology, or MS degree + at least 3 years of direct experience in a molecular and imaging histology lab, or BS degree + at least 10 years of direct experience in a molecular and imaging histology lab.

- Strong skillset in histotechniques (tissue processing and embedding, paraffin and cryo sectioning, special stains, automated immunohistochemistry, and in situ hybridization using Ventana Discovery Ultra or similar platform, whole slide scanning using Zeiss AxioScan or similar).

- Extensive practical experience in experimental design (e.g., validation of antibodies), execution (applying validated antibodies to tissue), and data analysis (imaging).

- Clearly record and organize data in electronic lab notebooks and shared drives.

Nice to Have Skills & Experience

- Experience working with human and murine brain, liver, lung, kidney, and/or joint tissues.

- Cell and tissue culture experience. Candidates with Precision Cut Tissue Slice experience using human and animal tissue are highly preferred.

- Hands-on experience with novel molecular histology techniques (e.g., RNAscope, spatial transcriptomics).

Job Description

One of our large pharmaceutical clients is actively looking to hire a Molecular Histologist with strong expertise in advanced histotechniques and quantitative image analysis. The successful candidate will perform molecular and imaging histology work across multiple therapeutic areas, primarily focusing on projects related to neurodegenerative, neuroinflammatory, renal, and liver diseases. This technology is used to validate human genetic targets, understand mechanisms of action, and confirm target engagement and effects on disease phenotypes in healthy and diseased tissues.

The scientist will join a team with expertise in cutting-edge technologies including human and animal precision cut tissue slice (PCTS) culture, molecular histology, complex in-vitro, ex-vivo, and in vivo models, high-content imaging, and more. The environment encourages interaction with internal experts from multiple disciplines such as AI/ML and statistics, facilitating the design, execution, and analysis of tissue biology experiments to support drug development.

Major roles include interacting with project teams to identify how histotechniques can support target validation and drug development, as well as designing, performing, and analyzing histology studies to meet project timelines. Responsibilities:

1. Use a broad knowledge of histotechnique (including microtomy, cryotomy, microscopy, automated IHC, ISH, etc.) to develop, validate, and implement assays.
2. Develop and evaluate automated and AI algorithms using image analysis software (HALO, Visiopharm, etc.) for quantitative data generation.
3. Maximize information from imaging readouts by collaborating with AI/ML and statistics teams.
4. Independently execute experiments, conduct data analyses, and deliver results timely.
5. Record data clearly in electronic lab notebooks and communicate results internally and externally.

This project lasts 12 months with potential extensions.

Compensation:

$43-48/hr, with exact pay varying based on skills, experience, and education.

Benefits start on the 31st day and include medical, dental, vision insurance, HSA, FSA, DCFSA options, and 401k with employer matching. Paid sick leave and other paid time off are also provided.

Seniority level

• Associate

Employment type

• Full-time

Job function

• Science

Industries

• Pharmaceutical Manufacturing