Modeling & Simulations Associate Director

Vertex Pharmaceuticals; Boston (MA); On-site; USD 168,000 - 252,000; Full time

Benefits offered by this job

Medical, dental, and vision benefits

Generous paid time off

Educational assistance programs

401(k) matching

Commuting subsidy

Job summary

Vertex Pharmaceuticals in Boston is looking for a Modeling & Simulations Associate Director to lead M&S strategies in drug development. You will collaborate with teams on critical decision making using state-of-the-art methodologies.

The ideal candidate has significant experience in quantitative pharmacology and leadership skills. This hybrid-eligible role offers competitive compensation, including bonuses and extensive benefits like paid time off and educational assistance.

Qualifications

• 6+ years experience in Pharmacometric application.
• Experience in clinical development teams.
• Strong hands-on experience with state-of-the-art modeling tools.

Responsibilities

• Develop and execute M&S plans for drug development.
• Contribute to decision making through extensive modeling.
• Support training and integrate new M&S tools.

Skills

Population PK and PKPD modeling

Mechanistic PKPD modeling

Clinical trial simulations

Leadership and influencing skills

Verbal and written communication

Education

Master's or PhD in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics

Tools

NonMem

PsN

R

Phoenix

Job description

## Modeling & Simulations Associate DirectorApplylocations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-29425**Job Description****General Summary:**The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization. This role determines, plans, and executes technically challenging analyses by using state of the art Modeling & Simulation methodologies to strongly contribute to critical decision making.**Key Duties and Responsibilities:*** As Modeling & Simulations (M&S) lead in one or more cross functional drug development teams, responsibilities include the development and execution of Modeling & Simulation plans and analyses fully integrated with the overall development plans.* By using state of the art Modeling & Simulation methodologies strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc.* Independently perform mechanism based PKPD and population PK and PKPD-analyses, Clinical trial simulations and other model based analyses on a regular basis.* Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate.**Knowledge and Skills:*** A specialized understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.* Excellent hands-on skills in population PK and PKPD modeling, mechanistic PKPD modeling, Clinical trial simulations, Disease progression modeling, etc.* Excellent skills in the use of NonMem, PsN, R, Phoenix, and similar tools.* Demonstrated strong leadership: collaborative and influencing skills.* Excellent, verbal and written communication skills.* In-depth experience working in clinical development teams and integrating the use of PK/PD modeling and/or modeling of complex biological system.**Education and Experience:*** Master's or PhD, with preference in Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling.* Typically requires the following: PhD and 6 years experience or Master's Degree and 10 years experience in the application of Pharmacometric and other Modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies.#LI-KM4**Pay Range:**$168,000 - $252,000**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**Hybrid-Eligible Or On-Site Eligible**Flex Eligibility Status:**In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-Hybrid