Member of Technical Staff, Backend

Mandolin; San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

A leading company in drug discovery is looking for a Senior Backend Engineer. You will architect a scalable, compliant, and modular platform for diverse customer workflows in healthcare. This high-impact role calls for extensive experience in backend systems, API design, and workflow orchestration frameworks to support rapid growth.

Qualifications

• 7+ years building and scaling backend systems in Node.js/TypeScript.
• Architectural ownership of a multi-tenant SaaS or platform.
• Hands-on expertise with workflow orchestration frameworks.

Responsibilities

• Design the core services including APIs and data contracts.
• Implement multi-tenancy and routing layers.
• Orchestrate workflows using engines like Temporal or Camunda.

Skills

Node.js

TypeScript

API design

Event-driven architecture

Microservices

High-throughput data stores

Workflow orchestration frameworks

Job description

About Mandolin

Nearly all disease will become treatable in our lifetimes, and drug discovery is quickly becoming an engineering discipline. Mandolin is building the “last-mile” delivery infrastructure that gets cutting-edge biologics, cell, and gene therapies to patients faster. Our AI-powered knowledge-worker platform already serves leading infusion clinics, with payers and pharma next in line.

We’re backed by Greylock, SignalFire, Maverick, and founders of famous companies like Yahoo, and led by repeat and exited founders with a team hailing from some of the most technically impressive companies.

Why we need you

Mandolin’s growth curve is steep: every new customer pushes fresh data formats, approval rules, and throughput targets. To keep pace, we need a rock-solid backend platform that:

• adapts to wildly different clinic and payer workflows via configuration, not code forks;

• scales from a single site to nationwide networks; and

• stays compliant in one of the most regulated industries on earth.

You’ll architect that foundation—turning a fast-moving codebase into a modular, multi-tenant platform that other engineers can extend in days, not sprints.

What you’ll do

• Design the core services – Define the APIs, data contracts, and plugin framework that let product teams drop new customer workflows into place without rewrites.

• Build for multi-tenancy – Implement tenancy, partitioning, and routing layers that isolate data, guarantee SLA boundaries, and satisfy compliance auditors.

• Orchestrate workflows – Use Temporal, Camunda, or similar engines to run thousands of long-lived, fault-tolerant jobs per customer.

• Raise the reliability bar – Own observability, graceful degradation, and performance guardrails that keep clinics online around the clock.

• Accelerate dev velocity – Establish testing, CI/CD, and code-review standards, and mentor engineers on scalable platform patterns.

• Partner across functions – Work with ML, data, and security teams to expose clean interfaces and ensure end-to-end traceability.

Must-have experience

• 7 + years building and scaling backend systems in Node.js / TypeScript (or comparable stacks).
  Architectural ownership of a multi-tenant SaaS or platform serving diverse customer requirements.

• Deep knowledge of API design, event-driven or microservice patterns, and high-throughput data stores.

• Hands-on expertise with workflow orchestration frameworks (Temporal, Camunda, Airflow, etc.).

• Track record of shipping resilient, observable services in production and leading incident retros.

• Passion for codifying best practices and coaching engineers through complex refactors.

Nice-to-haves

• Production experience in regulated domains (healthcare, fintech, or similar).

• Designing audit-ready security controls—encryption, RBAC, immutable logs.

• Building config-driven or DSL-based extension systems.

• Familiarity with GCP, service meshes, and zero-downtime deployment strategies.