Medical Science Liaison

Palvella Therapeutics, Inc.; United States; On-site; USD 130,000 - 190,000; Full time

Job summary

Palvella Therapeutics (NASDAQ: PVLA) seeks a Medical Science Liaison to advance scientific dialogue with dermatology and vascular anomaly experts, supporting late-stage and pre-commercial activities.

The role is field-based across the United States, with substantial travel (60–70%) and remote work within the US. The ideal candidate holds an advanced scientific degree and 3–5+ years in Medical Affairs or as an MSL, with a track record in rare skin diseases.

Qualifications

• Advanced scientific degree required (PharmD/MD/PhD/NP/PA or equivalent).
• 3–5+ years in Medical Affairs or as an MSL.
• Ability to communicate complex data to diverse audiences.
• Experience with rare dermatologic conditions preferred.

Responsibilities

• Deliver high-quality scientific exchange to dermatologists and investigators.
• Establish and maintain trusted relationships with key opinion leaders (KOLs).
• Communicate disease biology and QTORIN™ data with clarity and rigor.
• Support clinical development programs in microcystic lymphatic malformations and cutaneous venous malformations.
• Generate actionable field insights to inform Medical Affairs strategy.
• Partner cross-functionally with Clinical Development, Regulatory, and Commercial teams.
• Represent Palvella at dermatology, rare disease, and vascular anomaly congresses.
• Develop and refine medical materials and FAQs.
• Maintain current knowledge of mTOR biology and related data.
• Contribute to building a high-performing Medical Affairs organization.

Skills

MSL experience

Scientific exchange

Relationship building

Dermatology knowledge

KOL engagement

Education

Advanced scientific degree

PharmD/MD/PhD/NP/PA

Job description

Palvella Therapeutics (NASDAQ: PVLA) is a clinical-stage biopharmaceutical company developing innovative therapies for serious, rare skin and vascular conditions that currently have no FDA-approved therapies. With a pipeline of potentially first-in-disease assets and a clear path toward commercialization, Palvella offers a unique opportunity to join at a pivotal moment, helping bring meaningful therapies to patients with significant unmet medical needs.

At the core of Palvella’s innovation is its patented QTORIN™ platform, which is designed to deliver therapies directly to affected tissue while minimizing systemic exposure. The platform supports the development of topical therapies that penetrate deep into the layers of the skin, reflecting Palvella’s commitment to pairing scientific precision with real-world applicability for patients and clinicians.

Palvella’s lead product candidate, QTORIN™ rapamycin, is being evaluated in clinical programs for microcystic lymphatic malformations (mLM) and cutaneous venous malformations (cVM). With a potential first commercial launch anticipated in early 2027 in mLM, this is a pivotal time to join Palvella, contribute to building its first commercial organization, and make a direct impact on patients, families, and the broader rare skin disease community.

The company is gearing up for what will be a transformational year in 2026 by adding a number of leaders to the management team in preparation for commercialization in early 2027.

The Executive Team

You’ll be joining a passionate, agile, and deeply experienced leadership team, including:

• Wes Kaupinen, Founder and Chief Executive Officer
• Jeff Martini , Ph.D., Chief Scientific Officer
• Matthew Korenberg, Chief Financial Officer
• Kathy Goin, Chief Operating Officer
• David Osborne , Ph.D., Chief Innovation Officer

You will report directly to Vimal Patel, Senior Vice President, Medical Affairs

The Role: Medical Science Liaison / Senior Medical Science Liaison

The Medical Science Liaison (MSL) / Senior Medical Science Liaison (Senior MSL) is a field-based medical professional responsible for delivering high-quality, non-promotional scientific exchange and supporting clinical development activities across Palvella’s rare disease portfolio.

The level (MSL vs. Senior MSL) will be determined based on experience, therapeutic expertise, and demonstrated field impact. Both roles are hands-on, externally focused, and deeply connected to the science.

Key Highlights

The successful candidate is scientifically rigorous, externally credible, and deeply patient-focused. He or she will be motivated by advancing meaningful scientific dialogue in areas of high unmet need and by building trusted partnerships within the rare dermatology and vascularanomaly community. This individual will play a visible role in shaping Palvella’s Medical Affairs presence during a pivotal stage of late-stage development and pre-commercial readiness.

• Deliver high-quality, balanced scientific exchange to dermatologists, vascular anomaly specialists, geneticists, and clinical investigators across assigned territory.
• Establish and maintain trusted, long-term relationships with key opinion leaders, academic centers, and vascular anomaly clinics.
• Communicate complex disease biology, mTOR pathway science, and QTORIN™ clinical data with clarity and scientific rigor.
• Support ongoing and planned clinical programs in microcystic lymphatic malformations, cutaneous venous malformations, and other rare dermatologic conditions.
• Generate and share actionable field insights to inform Medical Affairs strategy, clinical development planning, and future launch readiness.
• Partner cross-functionally with Clinical Development, Regulatory, and Commercial colleagues to ensure aligned and compliant scientific engagement.
• Represent Palvella at key dermatology, rare disease, and vascular anomaly congresses and educational forums.
• Contribute to the development and refinement of medical materials, FAQs, and educational content.
• Maintain deep, current knowledge of mTOR biology and emerging data in rare dermatologic and vascular disorders.
• Play a visible role in building a high-performing, collaborative Medical Affairs organization during a pivotal stage of company growth.

Location & Work Model

This is a field-based, externally focused role with significant travel (approximately 60–70%) to support scientific engagement with key opinion leaders, investigators, and academic centers across the assigned territory. The MSL will operate remotely within the United States while maintaining strong alignment with cross-functional partners.

Palvella’s headquarters is located in suburban Philadelphia (Wayne, PA), and periodic travel to headquarters and national congresses will be expected.

Ideal Candidate Snapshot

• Advanced scientific degree (PharmD, MD, PhD, NP, PA, or equivalent) with strong foundational knowledge in dermatology, rare disease, immunology, vascular anomalies, or related therapeutic areas.
• 3–5+ years of experience in Medical Affairs or as a field-based MSL (level determined by experience), preferably supporting clinical-stage or pre-launch assets.
• Demonstrated ability to engage in high-level, evidence-based scientific exchange with dermatologists, academic investigators, and multidisciplinary specialty clinics.
• Experience working with or strong interest in rare disease populations, complex care models, and academic medical centers.
• Proven track record of building credible, trusted external relationships while maintaining compliance and scientific integrity.
• Strong ability to distill complex clinical and mechanistic data into clear, impactful dialogue tailored to diverse stakeholders.
• Collaborative mindset with experience partnering cross-functionally across Clinical Development, Regulatory, and Commercial teams.

Building the leading therapeutics company focused on rare genetic skin diseases with no approved therapies.