Mechanical Engineer 3, Consumables Sustaining

10x Genomics, Inc.; Pleasanton (CA); Hybrid; USD 127,000 - 172,000; Full time

Job summary

10x Genomics, Inc. seeks a Mechanical Engineer 3, Consumables Sustaining to join the MSE team in Pleasanton, CA. This role focuses on sustainment and technical stewardship of on-market consumables, collaborating with operations, R&D, and QA to drive issue resolution.

You will analyze field and manufacturing problems, lead root cause investigations, and support ECOs/ECRs, CAPAs, and QC method development with a strong plastics and precision molding background.

Qualifications

• BS or MS in Mechanical Engineering with 4+ years in mechanical design or sustaining engineering, including at least 3 years in biotech consumables.
• Plastics expertise with thermoplastics resins (COC, COP, PC, PP), elastomers (TPE/TPU), and precision injection molding.
• Strong understanding of 3D mechanical design, geometric tolerancing per ASME Y14.5, dimensional stack‑ups and inspection procedures.
• Experience with CAD, PDM, simulation suites, metrology and imaging equipment (OGP, Keyence, Nikon) and data analysis tools (JMP).
• Familiarity with Risk Management, Process capability (cpk, ppk), FMEA, and Gage R&R.

Responsibilities

• Cross-functional collaboration to design, develop and transfer new consumable components.
• Serve as mechanical contact for on-market consumables sustaining issues; communicate findings to stakeholders.
• Lead root-cause investigations and implement corrective actions; support manufacturing and quality processes.
• Drive on-market engineering changes (ECOs/ECRs) through change control; support CAPAs and QC method development.

Skills

Mechanical design

Geometric tolerancing

Root cause analysis

Cross-functional collaboration

Reliability improvement

Education

BS in Mechanical Engineering

MS in Mechanical Engineering

Tools

CAD

PDM systems

Simulation software

Metrology equipment (OGP, Keyence, Nikon)

JMP

Arena PLM

Oracle ERP

Job description

About the role: We are seeking an outstanding Mechanical Engineer 3, Consumables Sustaining to join the Manufacturing Systems Engineering (MSE) team at 10x Genomics. This is a key position for the sustainment and technical stewardship of on-market consumables products. This is a multi-disciplinary position that involves close collaboration with various groups including other operations functions (Supply Chain Management, Planning, Manufacturing, Quality Control) as well as Fluidics and R&D Engineering. You will play a key role in driving and supporting issue identification, root cause analysis and remediation.

The ideal candidate will have a proven track record in supporting complex plastic components for the life sciences or medical device industries. They should possess a broad understanding of the design and manufacturing of complex plastic systems and excel in solving complex problems. As a member of the team, you will be instrumental in supporting 10x manufacturing, supply chain, and service & support teams to support products that enable accelerated understanding of biology.

What you will be doing:

1. Cross-Functional Collaboration

• Support the design, development and transfer of new consumable components.
• Serve as mechanical point of contact for on-market consumables sustaining issues.
• Communicate findings and recommendations to cross-functional stakeholders across operations, commercial and R&D.

2. Root Cause Analysis and Sustaining Design

• Troubleshoot and resolve both field and manufacturing issues with consumables (e.g. LSR-thermoplastic assemblies and precision injection-molded COC/COP microfluidics).
• Lead/support root cause investigations (e.g. seal leaking, dimensional drift, biocompatibility, cracking) using FEA, tolerance analysis and hands‑on failure analysis. Implement and verify corrective actions.
• Support investigations into fluidic and microfluidic performance issues in partnership with broader sustaining and R&D engineering groups.

3. Manufacturing and Quality Support

• Drive on-market engineering changes (ECOs/ECRs) through change control process.
• Contribute to CAPAs, non-conformance investigations and support QC method development and deployment.
• Utilize Arena PLM and Oracle ERP systems to manage product lifecycle and manufacturing processes effectively.

4. Continuous Improvement

• Identify yield, reliability and quality improvement opportunities for on-market consumables.
• Support Gage R&R, FMEA and risk assessment of on-market consumable issues.

Minimum Requirements:

• Education: BS/MS in Mechanical Engineering.
• Experience: 6+ (BS) or 4+ (MS) years of experience in mechanical design or sustaining engineering, with at least 3 years specifically in biotech consumables.
• Plastics Expertise: Demonstrated knowledge and experience with thermoplastic resins (COC, COP, PC, PP), elastomers (TPE/TPU), and the nuances of precision injection molding.
• Engineering: Strong understanding of 3D mechanical design, geometric tolerancing per ASME Y14.5, dimensional stack-ups and inspection procedures.
• Tooling/Equipment: Demonstrated proficiency with CAD, PDM systems, simulation suites, metrology and imaging equipment (e.g. OGP, Keyence, Nikon) and data analysis tools (e.g. JMP).
• Quality Systems: Familiarity with Risk Management, Process capability (cpk, ppk), FMEA, and Gage R&R.

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Pay Range

$126,700—$171,500 USD

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.